Diamond S G, Markham C H, Treciokas L J
Ann Neurol. 1978 Mar;3(3):267-72. doi: 10.1002/ana.410030314.
A sixteen-week study examined the effect of Madopa and Sinemet on patients with Parkinson disease disease suffering nausea or vomiting as side-effects of levodopa therapy and compared the efficacy of the three preparations in controlling the symptoms of Parkinson disease. Following a control period on levodopa, 20 patients underwent four consecutive four-week regimens as follows: (1) double-blind, in which a randomized half received levodopa and half received Madopa; (2) single-blind, in which all received Madopa; (3) double-blind, in which a re-randomized half received Madopa and half Sinemet; and (4) single-blind, in which all received Sinemet. Levodopa administration via Sinemet and Madopa was held to a fixed 20% of prior levodopa dosage. Almost all patients showed great reduction in nausea and vomiting with both Madopa and Sinemet. Seventy percent of the patients showed improvement in disability compared to their levodopa baseline levels. Group means showed no difference between the improvement seen on Madopa and that seen on Sinemet. However, examination of individual responses showed that the majority of patients fared distinctly better on either Sinemet or Madopa.
一项为期16周的研究考察了美多芭和息宁对帕金森病患者的影响，这些患者因左旋多巴治疗出现恶心或呕吐等副作用，同时比较了这三种制剂控制帕金森病症状的疗效。在左旋多巴的对照期之后，20名患者接受了连续四个为期四周的治疗方案，具体如下：（1）双盲期，随机一半患者接受左旋多巴，另一半接受美多芭；（2）单盲期，所有患者均接受美多芭；（3）双盲期，重新随机一半患者接受美多芭，另一半接受息宁；（4）单盲期，所有患者均接受息宁。通过息宁和美多芭给予的左旋多巴剂量固定为先前左旋多巴剂量的20%。几乎所有患者使用美多芭和息宁后恶心和呕吐症状都大幅减轻。与左旋多巴基线水平相比，70%的患者残疾情况有所改善。组均值显示美多芭和息宁的改善情况没有差异。然而，对个体反应的检查表明，大多数患者使用息宁或美多芭后的情况明显更好。
