脂肪酸延长酶2基因多态性影响中国汉族人群患肺结核的风险。
Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population.
作者信息
Mu Min, Jing Li, Zou Yuan-Jie, Tao Xing-Rong, Wang Fei, Lu Jun
机构信息
Key Laboratory, Industrial Dust Control and Occupational Health, The Ministry of Education, Anhui University of Science and Technology, Anhui, China.
Department of Medical frontier Experimental Center, School of Medicine, Anhui University of Science and Technology, Anhui, China.
出版信息
Iran J Public Health. 2021 Nov;50(11):2254-2262. doi: 10.18502/ijph.v50i11.7580.
BACKGROUND
As an infectious disease closely related to , autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown.
METHODS
Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. , , and in gene were detected by Sanger sequencing.
RESULTS
Stratified by gender, the genotypes and allele frequencies of , and showed significant differences between the two groups (χ = 6.987, = 0.030), Genetic modeling showed that was statistically different in the overdominance model (χ = 4.784, OR = 1.414, 95% CI: 1.036-1.929, < 0.05). The polymorphism of between male TB patients and healthy controls was statistically different in the dominance model. (χ = 4.192, OR = 0.507; 95% CI: 0.262-0.981, < 0.05).
CONCLUSION
The of gene may be associated with susceptibility to TB in female population and the of gene may be associated with TB incidence in male patients.
背景
作为一种与自身免疫、炎症、环境和遗传密切相关的传染病，延长酶2基因单核苷酸多态性与结核病易感性之间的关系尚不清楚。
方法
2016年1月至2018年11月，开展了一项基于医院的病例对照研究。每三个月在两家医院进行一次这项流行病学调查。通过桑格测序检测基因中的、和。
结果
按性别分层，两组之间、和的基因型及等位基因频率存在显著差异（χ=6.987，=0.030），遗传模型显示在超显性模型中存在统计学差异（χ=4.784，OR=1.414，95%CI：1.036-1.929，<0.05）。男性结核病患者与健康对照之间基因的多态性在显性模型中存在统计学差异（χ=4.192，OR=0.507；95%CI：0.262-0.981，<0.05）。
结论
基因的可能与女性人群对结核病的易感性相关，基因的可能与男性患者的结核病发病率相关。
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