Sarin S K, Sachdev G, Nanda R, Batra S K, Anand B S
Gut. 1986 Jun;27(6):710-3. doi: 10.1136/gut.27.6.710.
To compare the efficacy and safety of one week versus three weeks interval treatment schedules of endoscopic sclerotherapy, injections were carried out in a prospective manner in 96 patients with variceal bleeding; 47 on a one week and 49 on a three weeks treatment schedule. Weekly endoscopic sclerotherapy eradicated oesophageal varices significantly (p less than 0.01) earlier (mean +/- SD 7.1 +/- 2.43 weeks) as compared with the three weeks regimen (mean +/- SD 14.86 +/- 4.86 weeks). The rebleeding rate was also significantly less (p less than 0.05) with weekly endoscopic sclerotherapy (8.5%) as compared with three weeks endoscopic sclerotherapy treatment (26.5%). The amount of alcohol and the number of endoscopic sclerotherapy courses required for complete variceal eradication did not differ significantly between the two groups. Patients undergoing weekly injections were seen to have significantly more oesophageal ulcers (p less than 0.01) as compared with the three weeks group, necessitating at times (23%) postponement of the procedure. There was, however, no difference between the two groups in the frequency of oesophageal stricture formation, dysphagia, retrosternal pain, and fever. Mortality was also similar in the two groups. It can be concluded that a weekly schedule of endoscopic sclerotherapy appears superior to a three weeks schedule.
为比较内镜下硬化治疗一周与三周间隔治疗方案的疗效和安全性，对96例静脉曲张出血患者进行了前瞻性注射治疗；47例采用一周治疗方案，49例采用三周治疗方案。与三周治疗方案（平均±标准差14.86±4.86周）相比，每周进行内镜下硬化治疗能显著更早地消除食管静脉曲张（p<0.01）（平均±标准差7.1±2.43周）。每周进行内镜下硬化治疗的再出血率（8.5%）也显著低于三周内镜下硬化治疗（26.5%）（p<0.05）。两组在完全消除静脉曲张所需的酒精量和内镜下硬化治疗疗程数方面无显著差异。与三周治疗组相比，每周接受注射的患者食管溃疡明显更多（p<0.01），有时需要推迟治疗（23%）。然而，两组在食管狭窄形成频率、吞咽困难、胸骨后疼痛和发热方面无差异。两组的死亡率也相似。可以得出结论，内镜下硬化治疗每周方案似乎优于三周方案。
