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新型冠状病毒肺炎患者恢复期血清中和抗体水平的变化

Changes in Serum Neutralizing Antibodies Levels During Convalescence of COVID-19 Patients.

作者信息

Chen Qing-Qing, Gong Lei, Wu Xiao-Min, Feng Ya-Ting, Luo Wan-Rong, Zhou Xue, Yuan Yuan, Yu Jun-Ling, He Lan, Wang Peng, Ge Ying-Lu, Hou Sai, Li Wei-Wei, Sun Yong, Wu Jia-Bing, Su Bin, Pan Hai-Feng, He Jun, Liu Zhi-Rong

机构信息

Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.

Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.

出版信息

Front Med (Lausanne). 2022 Feb 11;9:829273. doi: 10.3389/fmed.2022.829273. eCollection 2022.

DOI:10.3389/fmed.2022.829273
PMID:35223924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8879838/
Abstract

Detection of serum-specific SARS-CoV-2 antibody has become a complementary means for the identification of coronavirus disease 2019 (COVID-19). As we already know, the neutralizing antibody titers in patients with COVID-19 decrease during the course of time after convalescence, whereas the duration of antibody responses in the convalescent patients has not been defined clearly. In the current study, we collected 148 serum samples from 37 confirmed COVID-19 cases with different disease severities. The neutralizing antibodies (Nabs), IgM and IgG against COVID-19 were determined by CLIA Microparticle and microneutralization assay, respectively. The time duration of serum titers of SARS-CoV-2 antibodies were recorded. Our results indicate that IgG (94.44%) and Nabs (89.19%) can be detected at low levels within 190-266 days of disease onset. The findings can advance knowledge regarding the antibody detection results for COVID-19 patients and provide a method for evaluating the immune response after vaccination.

摘要

血清特异性严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）抗体检测已成为2019冠状病毒病（COVID-19）诊断的一种辅助手段。如我们所知，COVID-19患者康复后，其体内中和抗体滴度会随时间下降，而康复患者抗体反应的持续时间尚未明确界定。在本研究中，我们收集了37例确诊COVID-19患者的148份血清样本，这些患者病情严重程度各异。分别采用化学发光免疫分析微粒子法和微量中和试验检测针对COVID-19的中和抗体（Nabs）、IgM和IgG。记录SARS-CoV-2抗体血清滴度的持续时间。我们的结果表明，在发病后190 - 266天内可检测到低水平的IgG（94.44%）和Nabs（89.19%）。这些发现可增进对COVID-19患者抗体检测结果的了解，并为评估疫苗接种后的免疫反应提供一种方法。

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