McGrath Alysha M, Salyer Sarah A, Seelmann Amanda, Lundberg Alycen P, Leonard Melissa R, Lorbach Joshua N, Lumbrezer-Johnson Sarah, Hostnik Eric T, Tremolada Giovanni, Lapsley Janis, Selmic Laura E
Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, United States.
Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, United States.
Front Vet Sci. 2022 Feb 9;9:820956. doi: 10.3389/fvets.2022.820956. eCollection 2022.
This represents the first published case report of mediastinal fibrosarcoma in a dog. An 8-year-old male neutered mixed breed dog was presented for evaluation of lethargy and increased panting. Thoracic focused assessment with sonography for trauma revealed moderate pleural effusion. Thoracic radiograph findings were suggestive of a cranial mediastinal mass. Computed tomography revealed a mass within the right ventral aspect of the cranial mediastinum. On surgical exploration, a cranial mediastinal mass with an adhesion to the right cranial lung lobe was identified and removed en-bloc using a vessel sealant device and requiring a partial lung lobectomy. Histopathology results described the cranial mediastinal mass as fibrosarcoma with reactive mesothelial cells identified within the sternal lymph node. The patient was treated with systemic chemotherapy following surgical removal. To date, the dog has survived 223 days following diagnosis with recurrence noted 161 days following diagnosis and radiation therapy was initiated. Primary cranial mediastinal fibrosarcoma while a seemingly rare cause of thoracic pathology in dogs, should be considered in the differential diagnosis for a cranial mediastinal mass.
这是首篇发表的关于犬纵隔纤维肉瘤的病例报告。一只8岁已绝育的雄性混血犬因嗜睡和气喘加剧前来评估。胸部创伤超声重点评估显示中度胸腔积液。胸部X光片检查结果提示前纵隔肿块。计算机断层扫描显示在前纵隔右侧腹侧有一个肿块。手术探查时,发现一个与右肺前叶粘连的前纵隔肿块,使用血管封闭装置将其整块切除,且需要进行部分肺叶切除术。组织病理学结果将前纵隔肿块描述为纤维肉瘤,在胸骨淋巴结内发现有反应性间皮细胞。手术切除后对该犬进行了全身化疗。迄今为止,这只犬在确诊后存活了223天,确诊161天后出现复发并开始进行放射治疗。原发性前纵隔纤维肉瘤虽然看似是犬胸部病变的罕见病因,但在鉴别诊断前纵隔肿块时应予以考虑。