College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia.
Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan.
Biomed Res Int. 2022 Feb 16;2022:4620037. doi: 10.1155/2022/4620037. eCollection 2022.
COVID-19 is a global pandemic viral infection that has affected millions worldwide. Limited data is available on the effect of COVID-19 on hematological parameters in Saudi Arabia. This study is aimed at examining the role of hematological parameters among COVID-19 patients admitted to King Khalid Hospital in Najran, Saudi Arabia. This is a retrospective, hospital-based study of 514 cases who were recruited during August to October 2020. 257 COVID-19 patients formed the study group, and a further 257 negative subjects formed the control group. Anemia was significantly elevated in positive subjects over controls (respectively, 64.2% and 35.8%), with patients 2.5 times more likely to be anemic ( < 0.01). Thrombocytopenia was higher in patients over controls (respectively, 62% and 38%), with patients ~1.7 times more likely to be thrombocytopenic ( < 0.01). Moreover, leukopenia was significantly higher in patients over controls (respectively, 71% and 29%), with positive subjects ~2.6 times more likely to be leukopenic. Our study results indicate that mild anemia associated with leukopenia may have diagnostic value for COVID-19. Careful assessment of hematological parameters, at baseline and throughout the disease path, will assist physicians in formulating personalized approaches to treatment and promptly offer intensive care to those in greater need.
新型冠状病毒肺炎(COVID-19)是一种全球性的病毒性传染病,已在全球范围内影响了数百万人。目前有关 COVID-19 对沙特阿拉伯人群血液学参数影响的数据有限。本研究旨在研究沙特阿拉伯纳季兰国王哈利德国王医院收治的 COVID-19 患者的血液学参数的作用。这是一项回顾性的基于医院的研究,共纳入了 514 例患者,他们是在 2020 年 8 月至 10 月期间招募的。257 例 COVID-19 患者为研究组,另外 257 例阴性患者为对照组。阳性组的贫血发生率明显高于对照组(分别为 64.2%和 35.8%),贫血患者的患病风险增加了 2.5 倍( < 0.01)。血小板减少症在患者中也高于对照组(分别为 62%和 38%),血小板减少症患者的患病风险增加了 1.7 倍( < 0.01)。此外,白细胞减少症在患者中也明显高于对照组(分别为 71%和 29%),白细胞减少症患者的患病风险增加了 2.6 倍。我们的研究结果表明,轻度贫血伴白细胞减少可能对 COVID-19 具有诊断价值。在疾病发生的整个过程中,仔细评估血液学参数将有助于医生制定个性化的治疗方法,并及时为那些病情更严重的患者提供重症监护。