Theall Brandon, Alcaide Pilar
Department of Immunology, Tufts University School of Medicine, Boston, MA.
Immunology Program, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA.
Curr Opin Physiol. 2022 Feb;25. doi: 10.1016/j.cophys.2022.100484. Epub 2022 Jan 22.
The complex syndrome of heart failure (HF) is characterized by increased left ventricular pressures. Cardiomyocytes increase in size, cardiac fibroblasts transform and make extracellular matrix, and leukocytes infiltrate the cardiac tissue and alter cardiomyocyte and cardiac fibroblast function. Here we review recent advances in our understanding of the cellular composition of the heart during homeostasis and in response to cardiac pressure overload, with an emphasis on immune cell communication with cardiac fibroblasts and its consequences in cardiac remodeling.
心力衰竭（HF）这一复杂综合征的特征是左心室压力升高。心肌细胞体积增大，心脏成纤维细胞发生转化并生成细胞外基质，白细胞浸润心脏组织并改变心肌细胞和心脏成纤维细胞的功能。在此，我们综述了在稳态及心脏压力过载情况下，我们对心脏细胞组成理解的最新进展，重点关注免疫细胞与心脏成纤维细胞的通讯及其在心脏重塑中的后果。
