Mathur Ambika, Li Jacinda C, Lipitz Sarah R, Graham-Engeland Jennifer E
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA USA.
Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA USA.
Advers Resil Sci. 2022;3(1):1-19. doi: 10.1007/s42844-022-00051-3. Epub 2022 Feb 23.
Chronic inflammation is implicated in a variety of diseases (e.g., cardiovascular disease and cancer). Much evidence suggests that early life adversity (ELA), such as maltreatment or neglect, can increase risk for inflammation in adulthood. ELA may program proinflammatory activity via its effects on brain areas involved in emotion regulation. Of multiple emotion regulation strategies, some are considered maladaptive (e.g., expressive suppression), while others are generally adaptive (e.g., cognitive reappraisal). We propose a conceptual framework for how emotion regulation tendencies may affect vulnerability or resilience to inflammation in adults who experienced adversity in childhood and/or adolescence. In support of this framework, we summarize evidence for the relationships between emotion dysregulation and higher inflammation (i.e., vulnerability), as well as between cognitive reappraisal and lower inflammation (i.e., resilience), in healthy adults with a history of ELA. Plausible neurobiological, physiological, psychosocial, and ELA-specific factors, as well as interventions, contributing to these associations are discussed. Strengths and limitations of the extant research, in addition to ideas for future directions, are presented.
慢性炎症与多种疾病（如心血管疾病和癌症）有关。大量证据表明，早年逆境（ELA），如虐待或忽视，会增加成年后患炎症的风险。ELA可能通过其对参与情绪调节的脑区的影响来设定促炎活动。在多种情绪调节策略中，有些被认为是适应不良的（如表达抑制），而另一些通常是适应性的（如认知重评）。我们提出了一个概念框架，阐述情绪调节倾向如何影响童年和/或青少年时期经历过逆境的成年人对炎症的易感性或恢复力。为支持这一框架，我们总结了有ELA病史的健康成年人中情绪失调与较高炎症（即易感性）之间以及认知重评与较低炎症（即恢复力）之间关系的证据。讨论了促成这些关联的合理的神经生物学、生理学、心理社会和ELA特异性因素以及干预措施。介绍了现有研究的优势和局限性以及未来研究方向的思路。
