Komorowski J M, Komorowska A
Int J Obes. 1986;10(2):83-9.
In order to determine the role of the endogenous opiatergic system in modulation of human pancreatic B-cell function and taste perception, we measured the reactivity of gustatory receptors (electrogustometry), insulin and C-peptide serum concentration (radioimmunoassay) in six normal men (aged 24-26 years) during sham feeding and 0.8 mg of naloxone or placebo (saline) administration. We did not observe any differences in insulin and C-peptide concentrations during tease feeding independently of placebo or naloxone infusion. The verge of electric reactivity of gustatory perception significantly decreased in the period of food presentation and saline administration but did not change under naloxone. Our electrogustometry results support the hypothesis pointing out the role of endogenous opiates in modulation of human taste.
为了确定内源性阿片能系统在调节人类胰腺β细胞功能和味觉感知中的作用，我们测量了6名正常男性（年龄24 - 26岁）在假饲以及注射0.8毫克纳洛酮或安慰剂（生理盐水）期间味觉受体的反应性（电味觉测量法）、胰岛素和C肽血清浓度（放射免疫测定法）。在假饲期间，无论输注安慰剂还是纳洛酮，我们均未观察到胰岛素和C肽浓度有任何差异。在呈现食物和注射生理盐水期间，味觉感知的电反应阈值显著降低，但在注射纳洛酮时未发生变化。我们的电味觉测量结果支持了指出内源性阿片在调节人类味觉中作用的假说。
