Teff K L, Levin B E, Engelman K
Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104.
Am J Physiol. 1993 Dec;265(6 Pt 2):R1223-30. doi: 10.1152/ajpregu.1993.265.6.R1223.
To investigate the effect of oral sensory stimulation on cephalic phase insulin release (CPIR) and other compounds associated with glucose metabolism, a modified sham feed was used in which male subjects (n = 15) tasted, chewed, and then expectorated the food stimulus. Subjects remained fasted, sham fed, or ingested food on separate days over a 5-day period. After four baseline blood samples, poststimulus samples were taken every 2 min for 14 min and then every 15 min for 2.25 h. Increases in plasma insulin and C-peptide were found during the cephalic phase time period (0-10 min poststimulus) on the sham-fed and fed conditions when compared with fasted values. Glucose, norepinephrine, epinephrine, and free fatty acids were not affected by oral sensory stimulation or food ingestion during the cephalic phase period. The magnitude and profile of CPIR were similar after sham feeding and food ingestion. This study demonstrates that oral sensory stimulation can elicit CPIR in humans independently of changes in blood glucose.
为研究口腔感觉刺激对头期胰岛素释放（CPIR）及其他与葡萄糖代谢相关化合物的影响，采用了一种改良的假饲方法，让男性受试者（n = 15）品尝、咀嚼食物刺激物，然后吐出。在5天的时间里，受试者分别在空腹、假饲或进食的日子进行实验。采集4份基线血样后，刺激后每2分钟采集一次样本，共采集14分钟，然后每15分钟采集一次，共采集2.25小时。与空腹值相比，在假饲和进食条件下头期时间段（刺激后0 - 10分钟）血浆胰岛素和C肽水平升高。头期时间段内，口腔感觉刺激或食物摄入对葡萄糖、去甲肾上腺素、肾上腺素和游离脂肪酸没有影响。假饲和进食后CPIR的幅度和曲线相似。本研究表明，口腔感觉刺激可在不依赖血糖变化的情况下诱发人体CPIR。
