The University of Toledo, OH, USA.
The University of Toledo College of Medicine and Life Sciences, OH, USA.
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096211063066. doi: 10.1177/23247096211063066.
Malignancies have been associated with paraneoplastic syndromes, such as dermatomyositis. Subacute cutaneous lupus erythematosus (SCLE) can occur due to a wide array of cancers. Paraneoplastic SCLE obeys McLean's criteria and often regresses after the underlying malignancy has been treated appropriately. Anti-Ro/SSA antibodies are often present in patients with paraneoplastic SCLE; however, there have been many instances where anti-Ro may not be present. We report a case of non-Hodgkin lymphoma causing SCLE, a malignancy not previously known to be associated with paraneoplastic SCLE. We also highlight the importance of perhaps prompt chemotherapy to treat the underlying malignancy, as a failure to do so may lead to worse patient outcomes.
恶性肿瘤与副肿瘤综合征相关,如皮肌炎。亚急性皮肤型狼疮(SCLE)可由多种癌症引起。副肿瘤性 SCLE 符合 McLean 标准,并且通常在适当治疗基础恶性肿瘤后消退。抗 Ro/SSA 抗体常存在于副肿瘤性 SCLE 患者中;然而,也有许多情况下抗 Ro 可能不存在。我们报告了一例非霍奇金淋巴瘤引起的 SCLE,这是一种以前与副肿瘤性 SCLE 无关的恶性肿瘤。我们还强调了可能需要及时进行化疗以治疗基础恶性肿瘤的重要性,因为如果不这样做,可能会导致患者预后更差。