Rezazadegan R, Koushk-Jalali B, Kuntz T, Oellig F, Tigges C, Kreuter A
Klinik für Dermatologie, Venerologie und Allergologie, HELIOS St. Elisabeth Klinik Oberhausen, Universität Witten/Herdecke, Josefstr. 3, 46045, Oberhausen, Deutschland.
Institut für Pathologie, Mülheim an der Ruhr, Deutschland.
Z Rheumatol. 2021 Mar;80(2):189-193. doi: 10.1007/s00393-020-00926-9. Epub 2020 Nov 24.
Subacute cutaneous lupus erythematosus (SCLE) is a subtype of cutaneous lupus erythematosus characterized by high photosensitivity, the occurrence of annular or papulosquamous skin lesions located in body regions exposed to UV light, the presence of anti-Ro/SS‑A antibodies, and mild systemic involvement, such as arthralgia and myalgia. Similar to other subtypes of cutaneous lupus erythematosus, certain trigger factors exist for the development of SCLE, such as exposure to UV light, cigarette smoking and drugs. Rheumatic diseases, such as dermatomyositis, have been known as paraneoplastic syndromes for a long time. In recent years, there has been an accumulation of publications on the association of SCLE with malignant diseases. This article reports the case of a 78-year-old female patient who was diagnosed with the concomitant development of SCLE and gastric carcinoma. In all older patients with SCLE, patients with widespread skin affection outside the UV-exposed body areas or patients with B‑symptoms, the presence of a paraneoplastic SCLE should be considered and appropriate diagnostic steps should be initiated to screen for an associated neoplastic disease.
亚急性皮肤型红斑狼疮（SCLE）是皮肤型红斑狼疮的一种亚型，其特征为高度光敏性、在暴露于紫外线的身体部位出现环状或丘疹鳞屑性皮肤损害、存在抗Ro/SS - A抗体以及轻度的全身受累，如关节痛和肌痛。与皮肤型红斑狼疮的其他亚型类似，SCLE的发生存在某些触发因素，如暴露于紫外线、吸烟和药物。风湿性疾病，如皮肌炎，长期以来一直被认为是副肿瘤综合征。近年来，关于SCLE与恶性疾病关联的出版物不断积累。本文报告了一例78岁女性患者，该患者被诊断为同时患有SCLE和胃癌。在所有老年SCLE患者、紫外线暴露身体部位以外有广泛皮肤受累的患者或有B症状的患者中，应考虑副肿瘤性SCLE的存在，并应启动适当的诊断步骤以筛查相关的肿瘤性疾病。
