Department of Clinical Psychology, Yangzhou University Affiliated Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Department of Medical Image Center, Yangzhou University Affiliated Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Neurocase. 2022 Apr;28(2):246-250. doi: 10.1080/13554794.2022.2044861. Epub 2022 Feb 27.
Until recently, regional cerebral blood flow (rCBF) in major depressive disorder (MDD) patients treated with electroconvulsive therapy (ECT) using arterial spin labeling (ASL) magnetic resonance imaging (MRI) have seldom been studied. We report here 10 patients with MDD treated by bilateral frontotemporal ECT. rCBF was assessed with ASL MRI pre- and post-ECT, and compared with patients treated by antidepressants. Compared to pre-ECT, rCBF significantly decreased in the bilateral frontal gyrus. Compared to medication, in patients treated with ECT, rCBF showed a significant decrease in the left amygdala, parahippocampal and olfactory gyrus, and right occipital, lingual, calcarine gyrus, and significantly increased in the bilateral frontal gyrus and right frontal gyrus. Compared with antidepressants, ECT altered rCBF, and showed potential to be a superior treatment for major depressive disorder.
直到最近，使用动脉自旋标记（ASL）磁共振成像（MRI）对接受电惊厥疗法（ECT）治疗的重度抑郁症（MDD）患者的区域性脑血流（rCBF）的研究甚少。我们在此报告了 10 例接受双侧额颞叶 ECT 治疗的 MDD 患者。使用 ASL MRI 评估 rCBF，在 ECT 前后进行评估，并与接受抗抑郁药治疗的患者进行比较。与 ECT 前相比，双侧额回的 rCBF 显著降低。与药物治疗相比，ECT 治疗的患者的左杏仁核、海马旁回和嗅球以及右侧枕叶、舌回、楔前回 rCBF 显著降低，双侧额叶和右侧额叶 rCBF 显著增加。与抗抑郁药相比，ECT 改变了 rCBF，并且可能是治疗重度抑郁症的更好方法。
