Yu Yixing, Zong Manli, Lao Lifeng, Wen Jianzhu, Pan Daodong, Wu Zhen
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, School of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315211, Zhejiang, China.
School of Food Science & Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210097, P. R. China.
Food Funct. 2022 Mar 21;13(6):3098-3109. doi: 10.1039/d1fo04328e.
As a broadly defined member of lactic acid bacteria (LAB), the Lactobacillus strain is well characterized in food fermentation and specific strains can enhance the intestinal barrier function and be recognized as the probiotic strain. In recent years, many molecules of the cell surface are thought to be related to the adhesion property in the gastrointestinal mucosa. Mucus layer-related proteins, extracellular matrix proteins, and immunoglobulins also exhibit immunity regulation and protection of the intestinal epithelial barrier function. Meanwhile, the effects of bile and the low pH of the gastrointestinal tract (GIT) on Lactobacillus colonization are also needed to be considered. Furthermore, LAB can adhere and aggregate in the GIT to promote the maturity of biofilm and the extracellular matrix secreting through the signal molecules in the quorum sensing (QS) system. Therefore, it is of great interest to use the QS system to regulate the initial adhesion ability of Lactobacillus and further enhance the probiotic effect of the biofilm formation of beneficial bacteria. This review summarizes the adhesion properties of cell surface proteins derived from Lactobacillus strains in recent studies and provides valuable information on the QS effect on the adhesion property of Lactobacillus strains in the GIT environment.
作为乳酸菌（LAB）广义定义的成员，乳酸杆菌菌株在食品发酵方面具有良好的特性，特定菌株可增强肠道屏障功能并被视为益生菌菌株。近年来，许多细胞表面分子被认为与在胃肠道黏膜中的黏附特性有关。黏液层相关蛋白、细胞外基质蛋白和免疫球蛋白也表现出免疫调节和对肠道上皮屏障功能的保护作用。同时，还需要考虑胆汁和胃肠道（GIT）低pH值对乳酸杆菌定植的影响。此外，LAB可在GIT中黏附并聚集，通过群体感应（QS）系统中的信号分子促进生物膜成熟和细胞外基质分泌。因此，利用QS系统调节乳酸杆菌的初始黏附能力并进一步增强有益菌生物膜形成的益生菌效果具有重要意义。本综述总结了近期研究中乳酸杆菌菌株来源的细胞表面蛋白的黏附特性，并提供了关于QS对GIT环境中乳酸杆菌菌株黏附特性影响的有价值信息。
