Du Kaimin, Zhao Shuang, Feng Jing, Gao Xuan, Liu Kai, Wang Xiaozhen, Zhang Manli, Li Yao, Lu Yu, Zhang Hongjie
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.
University of Science and Technology of China, Hefei 230026, China.
J Mater Chem B. 2021 Sep 15;9(35):7216-7228. doi: 10.1039/d1tb00337b.
The integration of chemodynamic therapy (CDT) and photothermal therapy (PTT) has played a huge role in improved anticancer treatments. Here, a novel multifunctional nanoplatform based on CuS conjugated NaYF:Yb/Er@NaYF:Yb upconversion nanoparticles (UCNPs) was proposed and designed. In the UCNPs-CuS nanocomposites, UCNPs with excellent luminescent properties and a high X-ray attenuation coefficient can serve as an upconversion luminescence (UCL) and computer tomography (CT) imaging contrast agent; meanwhile, Cu(II) in the CuS nanodots enables the nanocomposites to have a magnetic resonance imaging (MRI) ability owing to the presence of unpaired electrons. Moreover, the CuS nanodots with a strong absorbance in the NIR II biowindow not only could be employed as a stable photothermal agent under NIR laser irradiation, but also could be used as a photothermal-enhanced Fenton nanocatalyst to respond to over-expressed HO in the tumor microenvironment (TME) and generate toxic hydroxyl radicals (˙OH) to effectively kill cancer cells. Furthermore, the UCNPs-CuS nanocomposites possess negligible cytotoxicity and a high photothermal conversion efficiency (43.8%) in the NIR-II biowindow (1064 nm), indicating that they possess great potential for the UCL/CT/MR multi-modal imaging guided synergistic enhanced CDT/PTT of cancer.
化学动力疗法（CDT）与光热疗法（PTT）的结合在改善抗癌治疗方面发挥了巨大作用。在此，我们提出并设计了一种基于硫化铜共轭的NaYF:Yb/Er@NaYF:Yb上转换纳米粒子（UCNPs）的新型多功能纳米平台。在UCNPs-CuS纳米复合材料中，具有优异发光性能和高X射线衰减系数的UCNPs可作为上转换发光（UCL）和计算机断层扫描（CT）成像造影剂；同时，由于未成对电子的存在，CuS纳米点中的Cu（II）使纳米复合材料具有磁共振成像（MRI）能力。此外，在近红外II生物窗口具有强吸收能力的CuS纳米点不仅可以在近红外激光照射下用作稳定的光热剂，还可以用作光热增强的芬顿纳米催化剂，以响应肿瘤微环境（TME）中过表达的HO并产生活性羟基自由基（˙OH）来有效杀死癌细胞。此外，UCNPs-CuS纳米复合材料在近红外II生物窗口（1064 nm）中具有可忽略不计的细胞毒性和高光热转换效率（43.8%），表明它们在UCL/CT/MR多模态成像引导的癌症协同增强CDT/PTT方面具有巨大潜力。
