Zellos Aglaia, Debray Dominique, Indolfi Giuseppe, Czubkowski Piotr, Samyn Marianne, Hadzic Nedim, Gupte Girish, Fischler Björn, Smets Françoise, de Cléty Stéphan Clément, Grenda Ryszard, Mozer Yael, Mancell Sara, Jahnel Jörg, Auzinger Georg, Worth Austen, Lisman Ton, Staufner Christian, Baumann Ulrich, Dhawan Anil, Alonso Estelle, Squires Robert H, Verkade Henkjan J
First Department of Pediatrics, Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Pediatric Hepatology Unit, Hôpital Necker-Enfants Malades, Reference Center for Rare Pediatric Liver Diseases, ERN Rare Liver and Transplant Child, Paris, France.
J Pediatr Gastroenterol Nutr. 2022 Mar 1;74(3):e45-e56. doi: 10.1097/MPG.0000000000003341.
The Hepatology Committee of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) aims to educate pediatric gastroenterologists, members of ESPGHAN and professionals from other specialties promoting an exchange of clinical expertise in the field of pediatric hepatology. Herewith we have concentrated on detailing the recent advances in acute liver failure in infants and children.
The 2020 ESPGHAN monothematic three-day conference on pediatric hepatology disease, entitled "acute liver failure" (ALF), was organized in Athens, Greece. ALF is a devastating disease with high mortality and most cases remain undiagnosed. As knowledge in diagnosis and treatment of ALF in infants and children has increased in the past decades, the objective was to update physicians in the field with the latest research and developments in early recognition, curative therapies and intensive care management, imaging techniques and treatment paradigms in these age groups.
In the first session, the definition, epidemiology, various causes of ALF, in neonates and older children and recurrent ALF (RALF) were discussed. The second session was dedicated to new aspects of ALF management including hepatic encephalopathy (HE), coagulopathy, intensive care interventions, acute on chronic liver failure, and the role of imaging in treatment and prognosis. Oral presentations by experts in various fields are summarized highlighting key learning points.
The current report summarizes the major learning points from this meeting. It also identifies areas where there is gap of knowledge, thereby identifying the research agenda for the near future.
欧洲儿科胃肠病学、肝病学和营养学会（ESPGHAN）肝病学委员会旨在对儿科胃肠病学家、ESPGHAN成员以及其他专业的专业人员进行培训，促进儿科肝病领域临床专业知识的交流。在此，我们着重详述了婴儿和儿童急性肝衰竭的最新进展。
2020年，ESPGHAN举办了为期三天的关于儿科肝病疾病的专题会议，主题为“急性肝衰竭”（ALF），会议在希腊雅典举行。急性肝衰竭是一种具有高死亡率的毁灭性疾病，大多数病例仍未得到诊断。在过去几十年中，婴儿和儿童急性肝衰竭的诊断和治疗知识有所增加，此次会议的目的是让该领域的医生了解这些年龄组在早期识别、治疗性疗法、重症监护管理、成像技术和治疗模式方面的最新研究和进展。
在第一场会议中，讨论了急性肝衰竭在新生儿和大龄儿童中的定义、流行病学、各种病因以及复发性急性肝衰竭（RALF）。第二场会议专门讨论了急性肝衰竭管理的新方面，包括肝性脑病（HE）、凝血病、重症监护干预、慢性肝病急性肝衰竭以及成像在治疗和预后中的作用。总结了各领域专家的口头报告，突出了关键的学习要点。
本报告总结了本次会议的主要学习要点。它还确定了存在知识差距的领域，从而确定了近期的研究议程。
