Petersen M J, Gammon W R, Briggaman R A
J Am Acad Dermatol. 1986 Jun;14(6):1014-9. doi: 10.1016/s0190-9622(86)70125-4.
We describe a case of linear IgA bullous disease initially presenting with histopathologic and immunofluorescent findings consistent with bullous pemphigoid. Initial immunofluorescent studies demonstrated a predominance of linear IgG at the basement membrane zone (BMZ) of perilesional skin and a low titer circulating IgG anti-BMZ antibody. Repeat studies 3 years later revealed a predominance of linear IgA immune deposits at the BMZ and no circulating anti-BMZ antibody. Dapsone therapy was initiated at this time with a good therapeutic response noted. Suction blister studies, immunoelectron microscopy, split skin immunofluorescent studies and Western immune blot were performed and provided indirect evidence that the BMZ antigen in this case is distinct from the bullous pemphigoid antigen component of the BMZ.
我们描述了一例线性IgA大疱性疾病，其最初的组织病理学和免疫荧光检查结果与大疱性类天疱疮一致。最初的免疫荧光研究显示，在病损周围皮肤的基底膜带（BMZ）主要为线性IgG，且循环IgG抗BMZ抗体滴度较低。3年后的重复研究显示，BMZ处主要为线性IgA免疫沉积物，且无循环抗BMZ抗体。此时开始使用氨苯砜治疗，观察到良好的治疗反应。进行了吸疱研究、免疫电镜检查、皮肤分层免疫荧光研究和免疫印迹法，提供了间接证据表明该病例中的BMZ抗原与BMZ的大疱性类天疱疮抗原成分不同。
