Simeonov Yuri, Weber Uli, Schuy Christoph, Engenhart-Cabillic Rita, Penchev Petar, Flatten Veronika, Zink Klemens
University of Applied Sciences, Institute of Medical Physics and Radiation Protection (IMPS), Giessen, Germany.
Philipps-University, Marburg, Germany.
Biomed Phys Eng Express. 2022 Mar 11;8(3). doi: 10.1088/2057-1976/ac5937.
The purpose of this work was to develop and manufacture a 3D range-modulator (3D RM) for a complex target contour for scanned proton therapy. The 3D RM is considered to be a viable technique for the very fast dose application in patient-specific tumors with only one fixed energy. The RM was developed based on a tumor from a patient CT and manufactured with high-quality 3D printing techniques with both polymer resin and aluminum. Monte Carlo simulations were utilized to investigate its modulating properties and the resulting dose distribution. Additionally, the simulation results were validated with measurements at the Marburg Ion-Beam Therapy Centre. For this purpose, a previously developed water phantom was used to conduct fast, automated high-resolution dose measurements. The results show a very good agreement between simulations and measurements and indicate that highly homogeneous dose distributions are possible. The delivered dose is conformed to the distal as well as to the proximal edge of the target. The 3D range-modulator concept combines a high degree of dose homogeneity and conformity, comparable to standard IMPT with very short irradiation times, promising clinically applicable dose distributions for lung and/or FLASH treatment, comparable and competitive to those from conventional irradiation techniques.
这项工作的目的是为扫描质子治疗的复杂靶区轮廓开发并制造一种三维射程调制器（3D RM）。3D RM被认为是一种可行的技术，可在仅使用一种固定能量的情况下，针对特定患者的肿瘤非常快速地施加剂量。该射程调制器是基于患者CT扫描的肿瘤而开发的，并采用高质量的3D打印技术，使用聚合物树脂和铝进行制造。利用蒙特卡罗模拟来研究其调制特性以及由此产生的剂量分布。此外，模拟结果在马尔堡离子束治疗中心通过测量进行了验证。为此，使用先前开发的水模体进行快速、自动化的高分辨率剂量测量。结果表明模拟与测量之间具有很好的一致性，并表明可以实现高度均匀的剂量分布。所输送的剂量与靶区的远端以及近端边缘相符。3D射程调制器概念结合了高度的剂量均匀性和适形性，与标准调强质子治疗相当，且照射时间非常短，有望为肺部和/或FLASH治疗提供临床适用的剂量分布，与传统照射技术的剂量分布相当且具有竞争力。
