Zink Klemens, Baumann Kilian Simon, Theiss Ulrike, Subtil Florentine, Lahrmann Sonja, Eberle Fabian, Adeberg Sebastian
Marburg Ion-Beam Therapy Center (MIT), Department of Radiotherapy and Radiation Oncology, Marburg University Hospital, Albrecht-Kossel-Strasse, Marburg, 35043 Germany.
Department of Radiotherapy and Radiooncology, Marburg University Hospital, Baldingerstrasse, Marburg, 35043 Germany.
Health Technol (Berl). 2024;14(5):929-938. doi: 10.1007/s12553-024-00881-4. Epub 2024 May 21.
The Marburg Ion-Beam Therapy Center (MIT) is one of two particle therapy centers in Germany that enables the treatment of patients with both protons and carbon ions. The facility was build by Siemens Healthineers and is one of only two centers worldwide built by Siemens (Marburg, Germany and Shanghai, China). The present report provides an overview of technical and clinical operations as well as research activities at MIT.
The MIT was completed in 2011 and uses a synchrotron for accelerating protons and carbon ions up to energies of 250 MeV/u and 430 MeV/u respectively. Three treatment rooms with a fixed horizontal beam-line and one room with a 45 degree beam angle are available.
Since the start of clinical operations in 2015, around 2.500 patients have been treated at MIT, about 40% with carbon ions and 60% with protons. Currently around 400 patients are treated each year. The majority of the patients suffered from benign and malign CNS tumors (around 40%) followed by head and neck tumors (around 23%). MIT is actively involved in clinical studies with its patients. In addition to clinical operations, there is active research at MIT in the fields of radiation biology and medical physics. The focus is on translational research to improve the treatment of H & N carcinomas and lung cancer (NSCLC). Moreover, intensive work is being carried out on the technical implementation of FLASH irradiation for research purposes.
The MIT is one of two centers worldwide that were built by Siemens Healtineers and has been successfully in clinical operation since 2015. The service provided by Siemens is guaranteed until 2030, the future after 2030 is currently under discussion.
马尔堡离子束治疗中心（MIT）是德国两个粒子治疗中心之一，能够使用质子和碳离子治疗患者。该设施由西门子医疗建造，是全球仅有的两个由西门子建造的中心之一（德国马尔堡和中国上海）。本报告概述了MIT的技术和临床运营以及研究活动。
MIT于2011年建成，使用一台同步加速器分别将质子和碳离子加速到250MeV/u和430MeV/u的能量。有三个配备固定水平束线的治疗室和一个束角为45度的治疗室。
自2015年开始临床运营以来，MIT已治疗了约2500名患者，其中约40%使用碳离子治疗，60%使用质子治疗。目前每年约有400名患者接受治疗。大多数患者患有良性和恶性中枢神经系统肿瘤（约40%），其次是头颈部肿瘤（约23%）。MIT积极参与针对其患者的临床研究。除了临床运营外，MIT还在放射生物学和医学物理领域开展积极的研究。重点是转化研究，以改善头颈部癌和肺癌（非小细胞肺癌）的治疗。此外，正在为研究目的大力开展FLASH照射的技术实施工作。
MIT是全球由西门子医疗建造的两个中心之一，自2015年以来已成功投入临床运营。西门子提供的服务在2030年前得到保障，2030年之后的未来目前正在商讨中。
