Tulane University School of Medicine, New Orleans, Louisiana U.S.
Department of Emergency Medicine, University of Iowa Department of Emergency Medicine, Iowa City, Iowa.
Undersea Hyperb Med. 2022 First Quarter;49(1):43-55.
Sepsis is a life-threatening condition for which new therapies are needed. The objective of this literature review was to compile evidence related to the use of hyperbaric oxygen (HBO2) therapy in sepsis. The goal of this analysis was to determine whether human trials are indicated. The study was designed as a narrative review of literature for studies of HBO2 therapy in sepsis. Literature was reviewed to understand potentially beneficial and harmful clinical and physiological effects of HBO2 therapy in animals with sepsis. HBO2 has several physiologic mechanisms which may be beneficial in sepsis, including restoration of mitochondrial function, improved microvascular function and organ perfusion, decreased capillary leak, improved cytokine profile, direct antimicrobial effects, and enhanced antibiotic function. The studies reviewed suggest that HBO2 therapy may be most effective if administered early and in high doses. Animal trials also show that HBO2 may provide protection to the gut mucosa by preventing bacterial translocation in sepsis. HBO2 has a potential to reduce organ failure through novel sepsis mechanisms not used in other therapies. Further human studies should be performed to better elucidate the role of HBO2 in improving sepsis clinical outcomes.
败血症是一种危及生命的病症，需要新的治疗方法。本文献综述的目的是汇编与高压氧（HBO2）治疗败血症相关的证据。本分析的目的是确定是否需要进行人体试验。这项研究是对败血症 HBO2 治疗研究的文献进行叙述性综述。对文献进行了回顾，以了解 HBO2 治疗对败血症动物的潜在有益和有害的临床和生理影响。HBO2 具有多种生理机制，可能对败血症有益，包括恢复线粒体功能、改善微血管功能和器官灌注、减少毛细血管渗漏、改善细胞因子谱、直接抗菌作用和增强抗生素功能。综述的研究表明，如果早期给予大剂量 HBO2 治疗，可能效果最佳。动物试验还表明，HBO2 通过防止败血症中的细菌易位，可能为肠道黏膜提供保护。HBO2 通过其他疗法未使用的新型败血症机制有潜力减少器官衰竭。应进行进一步的人体研究，以更好地阐明 HBO2 在改善败血症临床结果中的作用。
