Elsalem Lina, Khasawneh Ayat, Al Sheboul Suhaila
Jordan University of Science and Technology Faculty of Medicine, Department of Pharmacology, Irbid, Jordan
Royal Medical Services, Department of Clinical Pathology and Microbiology, Amman, Jordan
Turk J Pharm Sci. 2022 Feb 28;19(1):110-116. doi: 10.4274/tjps.galenos.2020.43078.
Antimicrobial resistance is considered a major health problem, worldwide. It is significantly associated with high morbidity and mortality rates. The current antibiotics have limited therapeutic efficacy in providing treatment for multidrug resistant bacteria. Accordingly, research in the antimicrobial field has been directed toward the discovery of new agents to overcome bacterial resistance. Antimicrobial peptides (AMP) have been extensively studied as potential antimicrobial agents with lower incidence of drug resistance compared to conventional antibiotics. WLBU2 is an engineered cationic AMP with promising antibacterial activity. It is composed of 24 amino acids including; 13 arginine, 8 valine and 3 tryptophan residues. Findings from and studies showed that WLBU2 is a potent peptide with a broad spectrum activity against Gram-positive, Gram-negative, multidrug resistant, and biofilm forming bacteria. Additionally, WLBU2 appears as a salt-resistant peptide with potential application for treatment of infections at conditions with disturbed normal salt homeostasis. Furthermore, WLBU2 was found as AMP with limited host toxicity. Recent investigations have shown that combination of WLBU2 with conventional antibiotics can result in synergism against resistant bacteria. In this review we highlight the evidence supporting the promising properties of WLBU2 as an antibacterial agent with potential applications for the treatment of infections caused by resistant bacteria.
抗微生物药物耐药性被认为是一个全球性的重大健康问题。它与高发病率和高死亡率显著相关。目前的抗生素在治疗多重耐药菌方面的治疗效果有限。因此，抗菌领域的研究一直致力于发现新的药物以克服细菌耐药性。抗菌肽（AMP）作为一种潜在的抗菌药物已被广泛研究，与传统抗生素相比，其耐药发生率较低。WLBU2是一种经过改造的阳离子抗菌肽，具有良好的抗菌活性。它由24个氨基酸组成，包括13个精氨酸、8个缬氨酸和3个色氨酸残基。[具体文献1]和[具体文献2]的研究结果表明，WLBU2是一种强效肽，对革兰氏阳性菌、革兰氏阴性菌、多重耐药菌和形成生物膜的细菌具有广谱活性。此外，WLBU2表现为一种耐盐肽，在正常盐稳态受到干扰的情况下具有治疗感染的潜在应用价值。此外，WLBU2被发现是一种对宿主毒性有限的抗菌肽。最近的研究表明，WLBU2与传统抗生素联合使用可产生针对耐药菌的协同作用。在这篇综述中，我们重点介绍了支持WLBU2作为一种抗菌剂具有良好特性的证据，其在治疗耐药菌引起的感染方面具有潜在应用价值。
