Section on Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Section on Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Center for Prevention of Cardiovascular Disease, Medical Center Boulevard, Winston Salem, NC 27157, USA.
Med Clin North Am. 2022 Mar;106(2):389-399. doi: 10.1016/j.mcna.2021.11.013.
Significant drug interactions contribute to hospitalizations, mortality, and health care costs. They often are preventable with a basic understanding of pharmacokinetics and pharmacodynamics. More than quarter of Americans above the age of 40 years take a statin, the most commonly used lipid-lowering therapy in modern times. Because of their pharmacokinetics, statins interact with numerous other drugs and substances, often in a manner that differs from statin to statin. This article provides an overview of important drug interactions for the most commonly used medications in preventive cardiology, with an emphasis on clinically significant interactions involving statins.
药物相互作用可导致住院、死亡和医疗费用增加。通过基本了解药代动力学和药效动力学，这些相互作用通常是可以预防的。超过四分之一的 40 岁以上美国人服用他汀类药物，这是现代最常用的降脂疗法。由于药代动力学的原因，他汀类药物与许多其他药物和物质相互作用，其方式通常因他汀类药物而异。本文概述了预防心脏病学中最常用药物的重要药物相互作用，重点介绍了涉及他汀类药物的具有临床意义的相互作用。
