Chandra Anupam, Takahashi Paul Y, McCoy Rozalina G, Thorsteinsdottir Bjoerg, Hanson Gregory J, Chaudhry Rajeev, Rahman Parvez A, Storlie Curtis B, Murphree Dennis H
Division of Community Internal Medicine, Mayo Clinic, Rochester, MN, USA; Division of Geriatric Medicine and Gerontology, Mayo Clinic, Rochester, MN, USA.
Division of Community Internal Medicine, Mayo Clinic, Rochester, MN, USA; Division of Geriatric Medicine and Gerontology, Mayo Clinic, Rochester, MN, USA.
J Am Med Dir Assoc. 2022 Aug;23(8):1403-1408. doi: 10.1016/j.jamda.2022.01.069. Epub 2022 Feb 25.
Hospitalized patients discharged to skilled nursing facilities (SNFs) for post-acute care are at high risk for adverse outcomes. Yet, absence of effective prognostic tools hinders optimal care planning and decision making. Our objective was to develop and validate a risk prediction model for 6-month all-cause death among hospitalized patients discharged to SNFs.
Retrospective cohort study.
Patients discharged from 1 of 2 hospitals to 1 of 10 SNFs for post-acute care in an integrated health care delivery system between January 1, 2009, and December 31, 2016.
Gradient-boosting machine modeling was used to predict all-cause death within 180 days of hospital discharge with use of patient demographic characteristics, comorbidities, pattern of prior health care use, and clinical parameters from the index hospitalization. Area under the receiver operating characteristic curve (AUC) was assessed for out-of-sample observations under 10-fold cross-validation.
We identified 9803 unique patients with 11,647 hospital-to-SNF discharges [mean (SD) age, 80.72 (9.71) years; female sex, 61.4%]. These discharges involved 9803 patients alive at 180 days and 1844 patients who died between day 1 and day 180 of discharge. Age, comorbid burden, health care use in prior 6 months, abnormal laboratory parameters, and mobility status during hospital stay were the most important predictors of 6-month death (model AUC, 0.82).
We derived a robust prediction model with parameters available at discharge to SNFs to calculate risk of death within 6 months. This work may be useful to guide other clinicians wishing to develop mortality prediction instruments specific to their post-acute SNF populations.
出院后入住专业护理机构(SNFs)接受急性后期护理的住院患者发生不良结局的风险很高。然而,缺乏有效的预后工具阻碍了最佳护理计划和决策制定。我们的目标是开发并验证一个针对出院后入住SNFs的住院患者6个月全因死亡的风险预测模型。
回顾性队列研究。
2009年1月1日至2016年12月31日期间,在一个综合医疗保健服务系统中,从2家医院中的1家出院后入住10家SNFs中的1家接受急性后期护理的患者。
使用梯度提升机模型,利用患者的人口统计学特征、合并症、既往医疗保健使用模式以及本次住院的临床参数,预测出院后180天内的全因死亡。在10倍交叉验证下,对样本外观察结果评估受试者工作特征曲线下面积(AUC)。
我们确定了9803名独特患者,他们有11647次从医院到SNFs的出院记录[平均(标准差)年龄,80.72(9.71)岁;女性,61.4%]。这些出院记录涉及9803名在180天时存活的患者和1844名在出院第1天至第180天之间死亡的患者。年龄、合并症负担、过去6个月的医疗保健使用情况、实验室参数异常以及住院期间的活动状态是6个月死亡的最重要预测因素(模型AUC,0.82)。
我们推导出了一个强大的预测模型,该模型使用出院时可获得的参数来计算入住SNFs患者6个月内死亡风险。这项工作可能有助于指导其他希望开发针对其急性后期SNFs人群的死亡率预测工具的临床医生。