Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), Suwon, Gyeonggi 16419, Republic of Korea; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.
Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.
J Control Release. 2022 May;345:1-19. doi: 10.1016/j.jconrel.2022.02.028. Epub 2022 Feb 25.
Inflammatory bowel diseases (IBDs) are idiopathic gastrointestinal inflammatory disorders featuring chronic intestinal inflammation. Although IBDs are increasingly becoming globally prevalent, the exact etiology of IBD remains obscure. Recently, the ability of various drugs for mucosal healing such as corticosteroids, antibiotics, and immunosuppressants has been proven. However, the delivery of free drugs is insufficient and inadequate since some patients have experienced reduced efficacy due to repeated administration and others have suffered side effects. In this regard, novel platforms based on biomaterials are required to deliver pharmaceutical agents to the damaged site with increased efficacy and reduced side effects. In this review, we summarize the most recent status of numerous biomaterials in treating IBD. This review addresses various nanoparticles, microparticles, and hydrogels recently prepared from natural polymers, lipids, synthetic polymers, and inorganic materials. These diverse biomaterials can be used as effective drug-delivery systems to promote colon-specific delivery and for the stable release of drugs in IBD treatments.
炎症性肠病（IBD）是一种特发性胃肠道炎症性疾病，以慢性肠道炎症为特征。尽管 IBD 在全球范围内的发病率越来越高，但 IBD 的确切病因仍不清楚。最近，各种具有黏膜愈合能力的药物，如皮质类固醇、抗生素和免疫抑制剂的疗效已得到证实。然而，由于一些患者因反复给药而疗效降低，另一些患者则出现副作用，因此游离药物的递送是不足够和不充分的。在这方面，需要基于生物材料的新型平台将药物递送到受损部位，以提高疗效，减少副作用。在这篇综述中，我们总结了治疗 IBD 的多种生物材料的最新现状。这篇综述涉及了最近由天然聚合物、脂质、合成聚合物和无机材料制备的各种纳米粒子、微粒子和水凝胶。这些不同的生物材料可以用作有效的药物递送系统，以促进结肠特异性递送，并在 IBD 治疗中稳定释放药物。
