Department of Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Department of Neuroradiology, Walton Centre NHS Foundation Trust, Liverpool, UK.
BMJ Case Rep. 2022 Feb 28;15(2):e245914. doi: 10.1136/bcr-2021-245914.
A 21-year-old patient presented with sudden-onset headache, visual disturbance and left hand incoordination. She was diagnosed with a left vertebral artery dissection of the V3 segment resulting in multiple cerebellar and cerebral infarcts. There were no risk factors for dissection other than recent COVID-19 infection. She was treated initially with antiplatelets, followed by anticoagulation, but experienced recurrent ischaemia. Although guidance suggests endovascular repair may be beneficial for patients with cerebral artery dissection (CAD) who experience recurrent strokes on medical therapy, evidence is limited. After multidisciplinary team consideration of the individual patient anatomy and risks and benefits of different endovascular techniques, the patient was treated with endovascular coiling. At 10 months follow-up, she had no further strokes and improving neurological symptoms. The case highlighted COVID-19 as a potential trigger for CAD and the use of endovascular coiling in preventing catastrophic cerebral ischaemia in CAD refractive to medical therapy.
一位 21 岁的患者突发头痛、视力障碍和左手协调障碍。她被诊断为左椎动脉 V3 段夹层,导致多发性小脑和脑梗死。除了最近感染 COVID-19 外,没有其他夹层的危险因素。她最初接受了抗血小板治疗,随后进行了抗凝治疗,但出现了反复缺血。尽管指南建议对于在药物治疗中反复发生脑动脉夹层(CAD)的患者,血管内修复可能有益,但证据有限。在多学科团队考虑患者个体解剖结构以及不同血管内技术的风险和益处后,该患者接受了血管内线圈栓塞治疗。在 10 个月的随访中,她没有再次发生中风,且神经症状有所改善。该病例提示 COVID-19 可能是 CAD 的潜在诱因,以及血管内线圈栓塞治疗在预防 CAD 对药物治疗有反应的灾难性脑缺血方面的作用。