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Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin.Meta-GWAS 揭示了与尿转铁蛋白排泄相关的新型遗传变异。
J Am Soc Nephrol. 2022 Mar;33(3):511-529. doi: 10.1681/ASN.2021040491.
2
Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium.在 NHLBI 转化组学精准医学（TOPMed）联盟中，对代表多种血统的 23732 人的 eGFR 进行全基因组序列分析。
EBioMedicine. 2021 Jan;63:103157. doi: 10.1016/j.ebiom.2020.103157. Epub 2021 Jan 6.
3
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.跨种族肾脏功能关联研究揭示了潜在的因果基因及其对肾脏特异性疾病病因的影响。
Nat Commun. 2019 Jan 3;10(1):29. doi: 10.1038/s41467-018-07867-7.
4
Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure.血清尿调蛋白：长期肾移植失败的生物标志物。
Am J Nephrol. 2018;47(4):275-282. doi: 10.1159/000489095. Epub 2018 Apr 26.
5
Associations of Urinary Uromodulin with Clinical Characteristics and Markers of Tubular Function in the General Population.普通人群中尿调蛋白与临床特征及肾小管功能标志物的关联
Clin J Am Soc Nephrol. 2016 Jan 7;11(1):70-80. doi: 10.2215/CJN.04230415. Epub 2015 Dec 18.
6
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression.常见的非编码 UMOD 基因变异通过增加尿调蛋白的表达引起盐敏感性高血压和肾脏损伤。
Nat Med. 2013 Dec;19(12):1655-60. doi: 10.1038/nm.3384. Epub 2013 Nov 3.
7
Determination of uromodulin in human urine: influence of storage and processing.尿调蛋白的测定：储存和处理的影响。
Nephrol Dial Transplant. 2014 Jan;29(1):136-45. doi: 10.1093/ndt/gft345. Epub 2013 Oct 3.
8
Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.非裔参与者的肾脏特征遗传关联揭示了新的肾功能相关基因座。
PLoS Genet. 2011 Sep;7(9):e1002264. doi: 10.1371/journal.pgen.1002264. Epub 2011 Sep 8.
9
Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.鉴定人尿调节蛋白为Tamm-Horsfall尿糖蛋白。
Science. 1987 Apr 3;236(4797):83-8. doi: 10.1126/science.3453112.

Urine Uromodulin and Genetics of its Variation.

作者信息

Franceschini Nora, Le Thu H

机构信息

Gillings School of Global Public Health, Chapel Hill, North Carolina

Division of Nephrology, University of Rochester Medical Center, Rochester, New York

出版信息

J Am Soc Nephrol. 2022 Mar;33(3):461-462. doi: 10.1681/ASN.2022010027.

DOI:10.1681/ASN.2022010027
PMID:35228296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8975060/
Abstract
摘要