Department of Respiratory Medicine, Kanazawa University Hospital, Japan.
Department of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Japan.
Intern Med. 2022 Oct 1;61(19):2931-2934. doi: 10.2169/internalmedicine.9143-21. Epub 2022 Feb 26.
A 38-year-old man with renal cell carcinoma was referred to our hospital because of a productive cough. He had received radiotherapy for lung metastasis and been treated with axitinib. Bronchoscopy revealed necrosis in the bronchi of the right middle and lower lobes. Culture of the necrotic bronchial specimen revealed methicillin-resistant Staphylococcus aureus (MRSA). Although radiotherapy in combination with axitinib carries a risk of causing airway toxicity, MRSA necrotizing bronchitis has not been reported. Physicians should consider the possibility of infectious necrotizing bronchitis if irradiated patients show prolonged respiratory symptoms.
一位 38 岁男性，患有肾细胞癌，因咳嗽有痰就诊于我院。他曾接受过肺转移的放射治疗，并接受过阿昔替尼治疗。支气管镜检查显示右肺中叶和下叶支气管坏死。坏死性支气管标本的培养显示耐甲氧西林金黄色葡萄球菌（MRSA）。虽然放射治疗联合阿昔替尼有引起气道毒性的风险，但尚未报道 MRSA 坏死性支气管炎。如果接受放射治疗的患者出现持续的呼吸道症状，医生应考虑感染性坏死性支气管炎的可能性。
