Hu Ying, Wang Jiancheng, Zeng Sha, Chen Mengxia, Zou Guilin, Li Yuxia, Zhu Lingyan, Xu Jixiong
Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, Jiangxi, 330006, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Feb 22;15:527-534. doi: 10.2147/DMSO.S347349. eCollection 2022.
The role of serum albumin in the risk of diabetic peripheral neuropathy (DPN) remains unclear. This study aimed to explore the relationship between serum albumin level and DPN, and to examine any possible effect modifiers among patients with type 2 diabetes mellitus.
This cross-sectional study was conducted in Jiangxi, China, from May 2012 to December 2014. Serum albumin levels were determined in 523 subjects, and the association between serum albumin level and DPN was evaluated using linear regression models (odds ratio [OR] and corresponding 95% confidence interval [CI]).
There was a significant inverse association between serum albumin level (per 1 g/L increment, OR 0.95 [95% CI 0.92-0.98]) and the risk of DPN. Accordingly, when serum albumin was assessed as quartiles, a significantly lower risk of DPN was found in participants in quartile 4 (OR 0.49 [95% CI 0.25-0.95]), compared with those in quartile 1. Consistently, higher albumin levels (≥35 g/L) were associated with decreased odds for DPN (OR 0.36 [95% CI 0.17-0.74]) compared with lower levels. Furthermore, the albumin-DPN association was significantly stronger in patients with a relatively high body mass index (BMI; ≥24 kg/m; OR 0.91 [95% CI 0.85-0.98]) than in those with a low BMI (<24 kg/m; OR 0.99 [95% CI 0.94-1.04]; for interaction = 0.042).
These data suggest that serum albumin level could be a novel risk factor for DPN among patients with type 2 diabetes and relatively high BMI (>24 kg/m).
血清白蛋白在糖尿病周围神经病变（DPN）风险中的作用仍不明确。本研究旨在探讨血清白蛋白水平与DPN之间的关系，并在2型糖尿病患者中检查任何可能的效应修饰因素。
本横断面研究于2012年5月至2014年12月在中国江西进行。测定了523名受试者的血清白蛋白水平，并使用线性回归模型（比值比[OR]和相应的95%置信区间[CI]）评估血清白蛋白水平与DPN之间的关联。
血清白蛋白水平（每增加1 g/L，OR 0.95[95%CI 0.92 - 0.98]）与DPN风险之间存在显著负相关。因此，当将血清白蛋白评估为四分位数时，与第1四分位数的参与者相比，第4四分位数的参与者中DPN风险显著降低（OR 0.49[95%CI 0.25 - 0.95]）。同样，与较低水平相比，较高的白蛋白水平（≥35 g/L）与DPN的较低比值相关（OR 0.36[95%CI 0.17 - 0.74]）。此外，在体重指数（BMI）相对较高（≥24 kg/m²；OR 0.91[95%CI 0.85 - 0.98]）的患者中，白蛋白与DPN的关联明显强于BMI较低（<24 kg/m²；OR 0.99[95%CI 0.94 - 1.04]；交互作用P = 0.042）的患者。
这些数据表明，血清白蛋白水平可能是2型糖尿病且BMI相对较高（>24 kg/m²）患者发生DPN的一个新的危险因素。
