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1
Towards SINEUP-based therapeutics: Design of an synthesized SINEUP RNA.
Mol Ther Nucleic Acids. 2022 Feb 2;27:1092-1102. doi: 10.1016/j.omtn.2022.01.021. eCollection 2022 Mar 8.
2
SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides.
Mol Ther Nucleic Acids. 2023 Apr 7;32:402-414. doi: 10.1016/j.omtn.2023.04.002. eCollection 2023 Jun 13.
4
Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation.
Methods Mol Biol. 2022;2434:63-87. doi: 10.1007/978-1-0716-2010-6_4.
5
Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation.
FEBS Lett. 2020 Dec;594(24):4357-4369. doi: 10.1002/1873-3468.13928. Epub 2020 Oct 4.
6
SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells.
Front Cell Neurosci. 2015 May 13;9:174. doi: 10.3389/fncel.2015.00174. eCollection 2015.
8
Identification of functional features of synthetic SINEUPs, antisense lncRNAs that specifically enhance protein translation.
PLoS One. 2018 Feb 7;13(2):e0183229. doi: 10.1371/journal.pone.0183229. eCollection 2018.
9
Engineering mammalian cell factories with SINEUP noncoding RNAs to improve translation of secreted proteins.
Gene. 2015 Sep 15;569(2):287-93. doi: 10.1016/j.gene.2015.05.070. Epub 2015 Jun 2.
10
Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs.
Comput Struct Biotechnol J. 2016 Oct 27;14:404-410. doi: 10.1016/j.csbj.2016.10.004. eCollection 2016.

引用本文的文献

2
Structural Features of 5' Untranslated Region in Translational Control of Eukaryotes.
Int J Mol Sci. 2025 Feb 25;26(5):1979. doi: 10.3390/ijms26051979.
3
HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA.
Front Mol Biosci. 2024 Sep 27;11:1443917. doi: 10.3389/fmolb.2024.1443917. eCollection 2024.
4
Real-time monitoring strategies for optimization of transcription and quality control of RNA.
Front Mol Biosci. 2023 Sep 11;10:1229246. doi: 10.3389/fmolb.2023.1229246. eCollection 2023.
5
SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides.
Mol Ther Nucleic Acids. 2023 Apr 7;32:402-414. doi: 10.1016/j.omtn.2023.04.002. eCollection 2023 Jun 13.
6
Natural antisense transcripts as drug targets.
Front Mol Biosci. 2022 Sep 27;9:978375. doi: 10.3389/fmolb.2022.978375. eCollection 2022.

本文引用的文献

1
SINEUPs: a novel toolbox for RNA therapeutics.
Essays Biochem. 2021 Oct 27;65(4):775-789. doi: 10.1042/EBC20200114.
2
SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies.
Nucleic Acids Res. 2020 Nov 18;48(20):11626-11644. doi: 10.1093/nar/gkaa814.
3
Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation.
FEBS Lett. 2020 Dec;594(24):4357-4369. doi: 10.1002/1873-3468.13928. Epub 2020 Oct 4.
4
RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges.
Pharmacol Rev. 2020 Oct;72(4):862-898. doi: 10.1124/pr.120.019554.
5
Paving the Road for RNA Therapeutics.
Trends Pharmacol Sci. 2020 Oct;41(10):755-775. doi: 10.1016/j.tips.2020.08.004. Epub 2020 Sep 3.
6
An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs.
Nucleic Acids Res. 2020 Sep 18;48(16):9346-9360. doi: 10.1093/nar/gkaa598.
9
SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson's Disease.
Mol Ther. 2020 Feb 5;28(2):642-652. doi: 10.1016/j.ymthe.2019.08.005. Epub 2019 Aug 16.
10
mRNA structure determines modification by pseudouridine synthase 1.
Nat Chem Biol. 2019 Oct;15(10):966-974. doi: 10.1038/s41589-019-0353-z. Epub 2019 Sep 2.

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