Shankar Malavika, Chowdhury Tutul, Gousy Nicole, Parthasarathi Ashwaghosha
Internal Medicine, Interfaith Medical Center, New York, USA.
Internal Medicine, One Brooklyn Health System, Brooklyn, USA.
Cureus. 2022 Jan 24;14(1):e21567. doi: 10.7759/cureus.21567. eCollection 2022 Jan.
Ketone-prone diabetes or Flatbush diabetes is being increasingly recognized worldwide. It is typically seen in obese middle-aged men with a family history of Type 2 DM. Atypicality in the onset of age and gender variation is increasingly observed worldwide. Predisposition to glucose desensitization is one of many unclear pathophysiologic mechanisms which is why extensive studies are obligatory. After intensive insulin therapy, many patients eventually become insulin-independent and attain euglycemia with oral hypoglycemic agents or with diet alone due to the recovered functionality of pancreatic beta cells. Our report sheds light on the atypicality of presentation and summarizes the main diagnostic features of this rare form of diabetes. Increased awareness of this entity can facilitate early diagnosis and management.
酮症倾向糖尿病或弗拉特布什糖尿病在全球范围内越来越受到认可。它通常见于有2型糖尿病家族史的肥胖中年男性。全球范围内越来越多地观察到发病年龄和性别差异的非典型性。葡萄糖脱敏易感性是众多尚不清楚的病理生理机制之一，这就是为什么必须进行广泛研究的原因。经过强化胰岛素治疗后，许多患者最终不再依赖胰岛素，由于胰腺β细胞功能恢复，通过口服降糖药或仅通过饮食即可实现血糖正常。我们的报告揭示了这种表现的非典型性，并总结了这种罕见糖尿病形式的主要诊断特征。提高对该疾病的认识有助于早期诊断和管理。
