Moskowitz R W, Kresina T F
J Rheumatol. 1986 Apr;13(2):391-6.
Femoral and tibial cartilage as well as synovium derived from knees of nonoperated, sham-operated and partially meniscectomized NZW rabbits were studied using fluorescein conjugated goat IgG, goat antirabbit IgM, IgG and C3. Nonoperated and sham-operated animals revealed negative or minimal staining. Cartilaginous tissues from animals after partial meniscectomy showed uniform deposition of rabbit IgG and C3 in parallel at the surface; contralateral knees from these animals were negative for similar staining patterns. The data indicate that IgG and C3 deposition occurs in experimental secondary osteoarthritis and that immune complex deposition may contribute to the pathology of osteoarthritis.
使用荧光素偶联的山羊IgG、山羊抗兔IgM、IgG和C3，对未手术、假手术和部分半月板切除的新西兰白兔膝关节的股骨和胫骨软骨以及滑膜进行了研究。未手术和假手术的动物显示阴性或最小染色。部分半月板切除术后动物的软骨组织在表面平行显示兔IgG和C3的均匀沉积；这些动物的对侧膝关节在类似染色模式下呈阴性。数据表明IgG和C3沉积发生在实验性继发性骨关节炎中，并且免疫复合物沉积可能导致骨关节炎的病理改变。
