Albini B, Ossi E, Neuland C, Noble B, Andres G
Lab Invest. 1979 Nov;41(5):446-54.
In the present study, deposition of antigen-antibody complexes in the ovarian follicles of the rabbit is described. Forty-one rabbits were immunized with multiple daily injections of bovine serum albumin. Twenty-two rabbits developed systemic chronic serum sickness. The ovaries of rabbits with systemic chronic serum sickness, those of the immunized rabbits that did not develop systemic chronic serum sickness, and those of the nonimmunized rabbits were studied by light, electron, and immunofluorescence microscopy. It was found that granular deposits of bovine serum albumin, rabbit IgG, and C3, presumably as antigen-antibody complexes, were frequently present in the zona pellucida of secondary and tertiary follicles, and in the corpora atretica of rabbits with systemic chronic serum sickness. The oocytes showed an increased number of vacuoles and phagosomes containing electron-opaque material. These observations may contribute to the study of immunologic mechanisms in the pathophysiology of the female reproductive system.
在本研究中，描述了抗原 - 抗体复合物在兔卵巢卵泡中的沉积情况。41只兔子每天多次注射牛血清白蛋白进行免疫。22只兔子发生了全身性慢性血清病。通过光学显微镜、电子显微镜和免疫荧光显微镜对发生全身性慢性血清病的兔子的卵巢、未发生全身性慢性血清病的免疫兔子的卵巢以及未免疫兔子的卵巢进行了研究。结果发现，在继发性和三级卵泡的透明带以及发生全身性慢性血清病的兔子的闭锁卵泡中，经常存在牛血清白蛋白、兔IgG和C3的颗粒状沉积物，推测为抗原 - 抗体复合物。卵母细胞显示含有电子不透明物质的空泡和吞噬体数量增加。这些观察结果可能有助于研究女性生殖系统病理生理学中的免疫机制。
