Sugai K, Imamura Y, Mihashi S, Ohba M, Kunikane K, Mori N, Baba S
J Toxicol Sci. 1986 May;11(2):135-43. doi: 10.2131/jts.11.135.
The plasma levels and urinary excretion of batroxobin administered to 6 species of animals were examined by an enzyme immunoassay method. Defibrinogenating effect of batroxobin was also studied in those species. The plasma levels of immunoreactive batroxobin disappeared exponentially in all the animals and differences in half-life were observed to occur according to species. The elimination half-life of immunoreactive batroxobin in the plasma was the largest in dogs, followed by rats, monkeys, guinea pigs, mice and rabbits. The extent of the defibrinogenating effect was also noted to vary according to the species, being greatest in dogs and then monkeys, mice, rats, guinea pigs and rabbits. Following the continuous infusion of batroxobin into dogs, its level in the plasma remained high over a considerable period of time and the defibrinogenating effect lasted in corresponding to its plasma level. The urinary excretion of immunoreactive batroxobin was quite small in these species, being 0.2-1.9% of the original dose.
采用酶免疫分析方法检测了给予6种动物的巴曲酶的血浆水平和尿排泄量。还研究了巴曲酶在这些动物中的去纤维蛋白原作用。免疫反应性巴曲酶的血浆水平在所有动物中均呈指数下降，且观察到半衰期因物种而异。免疫反应性巴曲酶在血浆中的消除半衰期在犬中最长，其次是大鼠、猴、豚鼠、小鼠和兔。去纤维蛋白原作用的程度也因物种而异，在犬中最大，其次是猴、小鼠、大鼠、豚鼠和兔。对犬持续输注巴曲酶后，其血浆水平在相当长一段时间内保持较高，去纤维蛋白原作用持续时间与血浆水平相对应。这些动物中免疫反应性巴曲酶的尿排泄量相当少，为初始剂量的0.2-1.9%。
