Tomita K, Muso E, Tamura T, Kawai C
Jpn Circ J. 1982 Jun;46(6):577-82. doi: 10.1253/jcj.46.577.
The effect of hypofibrinogenemia with batroxobin on proliferative glomerular lesions of Masugi nephritis was examined in the rat. Batroxobin-treated rats had a relatively low level of plasma fibrinogen and a reduction in glomerular fibrin deposition. Mean nuclear counts in the outer cortical glomeruli were less in the batroxobin-treated group than in the untreated group on the 7th day. However, the difference in the overall severity of the glomerular histologic lesions between the two groups was not significant. Continual injections of the same dosage of batroxobin failed to maintain hypofibrinogenemia, possibly due to the antibody formation. These results suggest that relatively low plasma levels of fibrinogen are obviously not effective enough to prevent the development of the proliferative lesions in rat Masugi nephritis.
在大鼠中研究了巴曲酶所致低纤维蛋白原血症对马杉肾炎增殖性肾小球病变的影响。接受巴曲酶治疗的大鼠血浆纤维蛋白原水平相对较低，肾小球纤维蛋白沉积减少。在第7天，巴曲酶治疗组外皮质肾小球的平均核计数低于未治疗组。然而，两组之间肾小球组织学病变的总体严重程度差异不显著。持续注射相同剂量的巴曲酶未能维持低纤维蛋白原血症，可能是由于抗体形成。这些结果表明，相对较低的血浆纤维蛋白原水平显然不足以有效预防大鼠马杉肾炎增殖性病变的发展。
