Department of Hygiene, Faculty of Medicine University of Banja Luka, 78000 Banja Luka, the Republic of Srpska, Bosnia & Herzegovina.
Department of Hygiene, Public Health Institute of Republic of Srpska, 78000 Banja Luka, the Republic of Srpska, Bosnia & Herzegovina.
Rev Cardiovasc Med. 2022 Feb 11;23(2):57. doi: 10.31083/j.rcm2302057.
Type 2 diabetes mellitus (T2DM) is commonly associated with hyperglycemia, dyslipidemia, oxidative stress and inflammation which are well known cardiovascular risk factors. Pomegranate peel polyphenols have a proven hypolipemic, antioxidant and anti-inflammatory activity. However, there is a lack of clinical studies that would confirm its antioxidant and anti-inflammatory effects in diabetic patients. The potential of pomegranate peel extract (PoPEx) to counteract inflammation and oxidative stress in T2DM patients was investigated. For this purpose, a randomized, double-blind placebo-controlled study involving adult T2DM patients treated with PoPEx or placebo for eight-weeks was conducted.
Patients were randomly divided into two groups: the first group (n = 30) received capsules containing PoPEx 250 mg twice daily, while the placebo group (n = 30) received placebo capsules twice daily. Plasma concentration of inflammatory factors (interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and high sensitivity C reactive protein (hsCRP)), oxidative stress biomarkers (thiobarbituric acid reactive substances (TBARS), nitrites (NO2-), superoxide anion radical (O2-), hydrogen peroxide (H2O2), total antioxidant capacity (TAC)), homocysteine and lipid profile were analyzed.
The PoPEx treatment showed a significant reduction of inflammatory factors (IL-6, TNF-α, hsCRP), oxidative stress biomarkers (TBARS, NO2-, O2-) and homocysteine, while the TAC was increased. Moreover, a significant improvement in lipid profile was observed in the PoPEx group. Additional analysis showed a significant inverse correlation between the decrements of all measured inflammatory markers and TAC in the PoPEx group.
The study demonstrated that eight-week-long PoPEx administration had favorable effects on inflammatory status and oxidative stress biomarkers in diabetic patients.
2 型糖尿病（T2DM）通常与高血糖、血脂异常、氧化应激和炎症有关，这些都是众所周知的心血管危险因素。石榴皮多酚具有已证实的降血脂、抗氧化和抗炎活性。然而，缺乏临床研究来证实其在糖尿病患者中的抗氧化和抗炎作用。本研究旨在探讨石榴皮提取物（PoPEx）在 T2DM 患者中对抗炎症和氧化应激的潜力。为此，进行了一项为期 8 周的随机、双盲、安慰剂对照研究，该研究纳入了接受 PoPEx 或安慰剂治疗的成年 T2DM 患者。
患者被随机分为两组：第一组（n=30）每天服用两次含有 250mg PoPEx 的胶囊，而安慰剂组（n=30）每天服用两次安慰剂胶囊。分析了两组患者血浆中炎症因子（白细胞介素 6（IL-6）、肿瘤坏死因子-α（TNF-α）和高敏 C 反应蛋白（hsCRP））、氧化应激生物标志物（硫代巴比妥酸反应物质（TBARS）、亚硝酸盐（NO2-）、超氧阴离子自由基（O2-）、过氧化氢（H2O2）、总抗氧化能力（TAC））、同型半胱氨酸和血脂谱的浓度。
PoPEx 治疗可显著降低炎症因子（IL-6、TNF-α、hsCRP）、氧化应激生物标志物（TBARS、NO2-、O2-）和同型半胱氨酸，同时增加 TAC。此外，PoPEx 组的血脂谱也得到了显著改善。进一步分析表明，PoPEx 组所有测量的炎症标志物的下降与 TAC 呈显著负相关。
本研究表明，为期 8 周的 PoPEx 给药对糖尿病患者的炎症状态和氧化应激生物标志物具有有利影响。
