Yang Luming, Zhu Kai, Wang Wenjuan, Sun Baofei, Luo Peng, Zhang Aihua
The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.
Front Pharmacol. 2025 Apr 22;16:1488113. doi: 10.3389/fphar.2025.1488113. eCollection 2025.
Arsenic is an environmental metalloid contaminant known to induce multi-system and multi-organ damage, yet the precise toxicological mechanisms remain unclear. Moreover, effective low-toxicity interventions or treatments are lacking. This study aims to investigate the potential ameliorative effects of Rosa roxburghii Tratt juice (RRTJ) on metabolic disorders in arsenicosis patients, with a focus on plasma metabolite profiles. Using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), we analyzed the plasma metabolic profiles of arsenicosis patients before and after RRTJ intervention. After RRTJ intervention, significant alterations were observed in the plasma levels of 61 metabolites, with 30 metabolites upregulated and 31 downregulated. These metabolites were predominantly involved in six key biological pathways, including taurine and hypotaurine metabolism, histidine metabolism, β-alanine metabolism, glycine, serine, and threonine metabolism, pentose and glucuronate interconversions, as well as cysteine and methionine metabolism. In conclusion, RRTJ intervention may effectively alleviate metabolic disorders associated with arsenic toxicity, potentially through its antioxidant, anti-inflammatory effects and regulation of methylation pathways.
砷是一种环境类金属污染物，已知会导致多系统和多器官损伤，但其确切的毒理学机制仍不清楚。此外，缺乏有效的低毒干预措施或治疗方法。本研究旨在探讨刺梨汁（RRTJ）对砷中毒患者代谢紊乱的潜在改善作用，重点关注血浆代谢物谱。我们使用超高效液相色谱-串联质谱（UHPLC-MS/MS）分析了RRTJ干预前后砷中毒患者的血浆代谢谱。RRTJ干预后，观察到61种代谢物的血浆水平有显著变化，其中30种代谢物上调，31种下调。这些代谢物主要参与六个关键生物途径，包括牛磺酸和亚牛磺酸代谢、组氨酸代谢、β-丙氨酸代谢、甘氨酸、丝氨酸和苏氨酸代谢、戊糖和葡萄糖醛酸相互转化以及半胱氨酸和甲硫氨酸代谢。总之，RRTJ干预可能通过其抗氧化、抗炎作用以及对甲基化途径的调节，有效减轻与砷毒性相关的代谢紊乱。
