F. Widjaja Inflammatory Bowel and Immunobiology Research Institute.
Division of Gastroenterology, Department of Medicine, and.
J Clin Invest. 2022 Mar 1;132(5). doi: 10.1172/JCI155786.
The gut microbiome is at the center of inflammatory bowel disease (IBD) pathogenesis and disease activity. While this has mainly been studied in the context of the bacterial microbiome, recent advances have provided tools for the study of host genetics and metagenomics of host-fungal interaction. Through these tools, strong evidence has emerged linking certain fungal taxa, such as Candida and Malassezia, with cellular and molecular pathways of IBD disease biology. Mouse models and human fecal microbial transplant also suggest that some disease-participatory bacteria and fungi may act not via the host directly, but via their fungal-bacterial ecologic interactions. We hope that these insights, and the study design and multi-omics strategies used to develop them, will facilitate the inclusion of the fungal community in basic and translational IBD research.
肠道微生物群是炎症性肠病（IBD）发病机制和疾病活动的核心。虽然这主要是在细菌微生物群的背景下进行研究的，但最近的进展为宿主遗传学和宿主-真菌相互作用的宏基因组学研究提供了工具。通过这些工具，已经有强有力的证据将某些真菌分类群（如念珠菌和糠秕马拉色菌）与 IBD 疾病生物学的细胞和分子途径联系起来。小鼠模型和人类粪便微生物移植也表明，一些参与疾病的细菌和真菌可能不是通过宿主直接作用，而是通过它们的真菌-细菌生态相互作用。我们希望这些见解，以及用于开发这些见解的研究设计和多组学策略，将有助于将真菌群落纳入 IBD 的基础和转化研究中。
