Department of Orthodontics, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India.
Department of Orthodontics, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India.
Indian J Dent Res. 2021 Jul-Sep;32(3):399-406. doi: 10.4103/ijdr.IJDR_59_20.
The aim of this study is to review studies evaluating the role of genetics in skeletal class II malocclusion.
To assess the scientific evidence associating the role of genes in skeletal class II malocclusion. Materials and Methods: A complete search across the electronic database through PubMed, Cochrane, LILACS, BMC and manual hand search of orthodontic journals were done till May 2019. The keywords for the search included: "Genetics", "class II malocclusion", "maxillary prognathism", "mandibular retrognathism".
Studies were selected based on PRISMA guidelines.
Articles were selected based on the inclusion and exclusion criteria. A total of 11 cross-sectional studies satisfied the inclusion criteria and were analyzed for the role of genes in skeletal class II malocclusion. Almost all the studies except for one revealed a positive correlation of genes with skeletal class II malocclusion.
Out of the 11 studies included, a positive correlation of the genes with the skeletal II malocclusion was found in 10 studies. Genes FGFR2, MSX1, MATN1, MYOH1, ACTN3, GHR, KAT6B, HDAC4, AJUBA were found to be positively linked to skeletal class II malocclusion.
本研究旨在回顾评估遗传学在骨骼 II 类错颌畸形中作用的研究。
评估与骨骼 II 类错颌畸形相关的基因作用的科学证据。
通过 PubMed、Cochrane、LILACS、BMC 电子数据库全面检索，并对正畸杂志进行手工检索，检索时间截至 2019 年 5 月。检索的关键词包括：“遗传学”、“II 类错颌畸形”、“上颌前突”、“下颌后缩”。
根据 PRISMA 指南选择研究。
根据纳入和排除标准选择文章。共有 11 项横断面研究符合纳入标准，分析了基因在骨骼 II 类错颌畸形中的作用。除了一项研究外，几乎所有的研究都表明基因与骨骼 II 类错颌畸形之间存在正相关关系。
在所纳入的 11 项研究中，有 10 项研究发现基因与骨骼 II 类错颌畸形存在正相关。FGFR2、MSX1、MATN1、MYOH1、ACTN3、GHR、KAT6B、HDAC4、AJUBA 基因与骨骼 II 类错颌畸形呈正相关。
