Department of Internal Medicine, Division of Nephrology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.
Department of Statistics, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.
Saudi J Kidney Dis Transpl. 2021 Jul-Aug;32(4):979-985. doi: 10.4103/1319-2442.338310.
Kidney donor profile index (KDPI) is a method developed to assess donor kidney quality for cadaveric transplants. We investigated the relationship between kidney donor risk index (KDRI) and KDPI scores of cadaveric transplants in the last five years in our clinic and current graft conditions. Forty people (12 females, 28 males; mean age, 46.35 + 8.94 years), who underwent cadaveric transplantation between January 2013 and March 2018, were participated in this study. At the same time, the KPDI and KDRI scores of the donor's kidneys were calculated and then compared with that of the recipients' data. The mean KDRI value of donors was 1.11 ± 0.33 and the median KDPI value was 60.50%. KDRI/KDPI scores were found to be high in women (P = 0.021) and, when the posttransplant findings of the recipients were evaluated by bivariate correlation analysis KDRI/KDPI scores were positively correlated with the day when creatinine (Cr) values started to fall off spontaneously (r = 0.457, P = 0.003). It was observed that recipients who were transplanted from the donors with high KDRI/KDPI scores had higher Cr levels (P <0.01) and this relationship did not change over time (P = 0.115). When the donors were grouped as the standard-criteria donor and expanded-criteria donor (ECD); we found that the relationship between KDRI/KDPI, creatinine, and time was more significant in the ECD group (P = 0.04). KDRI/KDPI scores are closely related to graft outcomes especially in recipients that have kidneys from marginal donors. Therefore, evaluation of KDRI/KDPI scores might be required in marginal donors.
肾移植供者风险指数（KDRI）和供肾 KDPI 评分与移植肾近期预后的关系 目的 本研究旨在分析本中心近 5 年肾移植受者的 KDRI 评分与供者 KDPI 评分的关系及其与移植肾近期预后的关系。方法 回顾性分析 2013 年 1 月至 2018 年 3 月在我中心行肾移植术的 40 例患者的临床资料，男 28 例，女 12 例，年龄（46.35 ± 8.94）岁。同时计算供者的 KDRI 评分和 KDPI 评分，并与受者的术后随访资料进行对比分析。结果 供者的 KDRI 评分中位数为 1.11 ± 0.33，KDPI 评分中位数为 60.50%。女性供者的 KDRI 评分和 KDPI 评分均高于男性（P = 0.021）。进一步分析发现，KDRI/KDPI 评分与移植后血肌酐（Cr）下降至正常时间呈正相关（r = 0.457，P = 0.003）。此外，高 KDRI/KDPI 评分组的受者术后早期 Cr 水平更高（P <0.01），且这种关系不受时间影响（P = 0.115）。按照供者来源将供者分为标准供者和扩展标准供者，结果显示，在扩展标准供者中，KDRI/KDPI 评分与 Cr 及时间的关系更为密切（P = 0.04）。结论 KDRI/KDPI 评分与移植肾近期预后密切相关，尤其是在边缘供肾中。因此，对于边缘供肾，评估 KDRI/KDPI 评分可能具有重要意义。
