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当高肾捐献者特征指数标记的供体肾脏时,其被废弃的比例更高。

Deceased donor kidneys are discarded at higher rates when labeled as high kidney donor profile index.

机构信息

Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, Washington, USA.

Clinical and Bio-Analytics Transplant Laboratory (CBATL), University of Washington, Seattle, Washington, USA.

出版信息

Am J Transplant. 2022 Dec;22(12):3087-3092. doi: 10.1111/ajt.17197. Epub 2022 Sep 19.

Abstract

The kidney donor risk index (KDRI) and percentile conversion, kidney donor profile index (KDPI), provide a continuous measure of donor quality. Kidneys with a KDPI >85% (KDPI ) are referred to as "high KDPI." The KDPI cutoff changes every year, impacting which kidneys are labeled as KDPI . We examine kidney utilization around the KDPI cutoff and explore the "high KDPI" labeling effect. KDRI to KDPI Mapping Tables from 2012 to 2020 were used to determine the yearly KDRI value. Organ Procurement and Transplantation Network data was used to calculate discard rates and model organ use. KDRI varied between 1.768 and 1.888. In a multivariable analysis, kidney utilization was lower for KDPI 86% compared with KDPI 85% kidneys (p = .046). Kidneys with a KDRI between 1.785-1.849 were classified as KDPI in the years 2015-2017 and KDPI in the years 2018-2020. The discard rate was 44.9% when labeled as KDPI and 39.1% when labeled as KDPI (p < .01). For kidneys with the same KDRI, the high KDPI label is associated with increased discard. We should reconsider the appropriateness of the "high KDPI" label.

摘要

肾捐赠者风险指数(KDRI)和百分位转换,肾捐赠者特征指数(KDPI),为捐赠者的质量提供了一个连续的衡量标准。KDPI 大于 85%(KDPI)的肾脏被称为“高 KDPI”。KDPI 的截止值每年都会发生变化,这影响了哪些肾脏被标记为 KDPI。我们检查了 KDPI 截止值周围的肾脏利用情况,并探讨了“高 KDPI”标记的影响。使用 2012 年至 2020 年的 KDRI 到 KDPI 映射表来确定每年的 KDRI 值。使用器官采购和移植网络数据来计算废弃率并建立器官使用模型。KDRI 在 1.768 到 1.888 之间变化。在多变量分析中,与 KDPI 85%的肾脏相比,KDPI 86%的肾脏的利用率较低(p=0.046)。在 2015 年至 2017 年期间,KDRI 在 1.785-1.849 之间的肾脏被归类为 KDPI,而在 2018 年至 2020 年期间则被归类为 KDPI。当被标记为 KDPI 时,废弃率为 44.9%,当被标记为 KDPI 时,废弃率为 39.1%(p<0.01)。对于具有相同 KDRI 的肾脏,高 KDPI 标签与增加的废弃率相关。我们应该重新考虑“高 KDPI”标签的适当性。

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