Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Pediatr Dermatol. 2022 May;39(3):400-408. doi: 10.1111/pde.14967. Epub 2022 Mar 1.
Studies concerning pediatric lichen sclerosus are limited, and, to date, there have been no studies comparing the course of lichen sclerosus in boys and girls. We sought to examine all publications on boys and girls with lichen sclerosus and assess and compare epidemiology, symptoms and signs, genetic background, risk factors, treatment, and prognosis.
A systematic search was performed in the Embase, Medline, Cochrane, and Web of Science databases. Inclusion criteria were information on children ages 0-18 years and a clinical or histologic diagnosis of lichen sclerosus. Literature from 1985 to 2021 was reviewed.
A total of 1780 articles were retrieved from the search, of which 90 articles were eligible for inclusion. Boys and girls present similarly on many aspects; nonetheless, treatment and follow-up are approached differently.
Though the clinical approach is often different, lichen sclerosus in boys and girls demonstrates many similarities. More research is needed, especially on follow-up, to gain a better understanding of the course of lichen sclerosus and establish an advanced management plan for children.
儿科硬化性苔藓的研究有限，迄今为止，尚无比较男孩和女孩硬化性苔藓病程的研究。我们旨在研究所有关于男孩和女孩硬化性苔藓的出版物，并评估和比较流行病学、症状和体征、遗传背景、危险因素、治疗和预后。
在 Embase、Medline、Cochrane 和 Web of Science 数据库中进行了系统搜索。纳入标准为年龄 0-18 岁的儿童信息，以及临床或组织学诊断为硬化性苔藓。对 1985 年至 2021 年的文献进行了综述。
从检索中总共检索到 1780 篇文章，其中有 90 篇符合纳入标准。男孩和女孩在许多方面表现相似；尽管如此，治疗和随访的方法却不同。
尽管临床方法往往不同，但男孩和女孩的硬化性苔藓有许多相似之处。需要更多的研究，特别是在随访方面，以更好地了解硬化性苔藓的病程，并为儿童制定更先进的管理计划。
