Du Toit D F, Heydenrych J J, Smit B, Louw G, Zuurmond T, Laker L, Els D, Weideman A, Wolfe-Coote S, Du Toit L B
J Surg Oncol. 1986 May;32(1):1-7. doi: 10.1002/jso.2930320102.
The object of this preliminary study was to evaluate the endocrine function after heterotopic intraperitoneal segmental pancreatic allotransplantation with unligated duct in irradiated, totally pancreatectomized primates. All allograft recipients received, pre- and peroperative donor-specific blood transfusions and peroperative external irradiation from a linear accelerator; 200 rads was administered weekly and increased to a total dose of 1,500 rads. Pancreatic transplantation was performed between 2 and 6 weeks after completion of irradiation and preoperative blood transfusions. As previously reported, only minimal pancreatic allograft survival was achieved following preoperative irradiation. One recipient remained normoglycaemic for greater than 100 days after transplantation, the longest surviving pancreatic allograft recipient reported from this laboratory. Intravenous glucose tolerance test results in this recipient revealed normoglycaemia, reduced K-value, hypoinsulinaemia, normal glucagon response, reduced C-peptide values, and moderate glucose intolerance. Aortography and electron-microscopic examination of allograft biopsy tissue confirmed the presence of a functioning allograft.
这项初步研究的目的是评估在接受照射、全胰切除的灵长类动物中，进行未结扎胰管的异位腹腔节段性胰腺同种异体移植后的内分泌功能。所有同种异体移植受体在术前和术中接受供体特异性输血，并在术中接受直线加速器的外照射；每周给予200拉德，总剂量增至1500拉德。在照射和术前输血完成后2至6周进行胰腺移植。如先前报道，术前照射后同种异体胰腺移植的存活时间极短。一名受体在移植后血糖正常超过100天，这是该实验室报道的同种异体胰腺移植受体存活时间最长的。该受体的静脉葡萄糖耐量试验结果显示血糖正常、K值降低、胰岛素血症降低、胰高血糖素反应正常、C肽值降低以及中度葡萄糖不耐受。同种异体移植活检组织的主动脉造影和电子显微镜检查证实存在功能正常的同种异体移植。
