Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
Mol Cell Biochem. 2022 Jun;477(6):1645-1652. doi: 10.1007/s11010-022-04397-1. Epub 2022 Mar 1.
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects premature newborns. Many different factors, increasingly genetic, are involved in the pathogenesis of BPD. The aim of the study is to investigate the possible influence of fibronectin SNP on the occurrence of BPD. The study included 108 infants born between 24 and 32 weeks of gestation. BPD was diagnosed based on the National Institutes of Health Consensus definition. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655. BPD developed in 30 (27.8%) out of the 108 preterm infants. Incidence of BPD was higher in infants with lower APGAR scores and low birthweight. Investigation did not confirm any significant prevalence for BPD development in any genotypes and alleles of FN1. Further studies should be performed to confirm the role of genetic factors in etiology and pathogenesis of BPD.
支气管肺发育不良（BPD）是一种主要影响早产儿的慢性肺部疾病。许多不同的因素，包括遗传因素，都参与了 BPD 的发病机制。本研究旨在探讨纤连蛋白 SNP 对 BPD 发生的可能影响。该研究纳入了 108 名胎龄在 24 至 32 周之间的婴儿。BPD 的诊断基于美国国立卫生研究院共识定义。本研究评估了 5 个 FN1 基因多态性，分别是 rs3796123、rs1968510、rs10202709、rs6725958 和 rs35343655。在 108 名早产儿中，有 30 名（27.8%）发生了 BPD。APGAR 评分较低和出生体重较低的婴儿中，BPD 的发生率更高。研究未证实 FN1 的任何基因型和等位基因与 BPD 发展有显著相关性。应进一步开展研究以确认遗传因素在 BPD 的病因和发病机制中的作用。
