A novel and effective item-source complex trial protocol: Discrimination of guilty from both knowledgeable and unknowledgeable innocent subjects.

Innocent subjects who are knowledgeable of crime-related information will often be misclassified as "guilty" in P300-based complex trial protocol (CTP). Therefore, it is necessary to develop a more rigorous CTP that can effectively discriminate the guilty from both the knowledgeable and the unknowledgeable innocents. Sometimes the guilty and the knowledgeable innocents possess the same item memories but different source memories. The present study designed a novel item-source complex trial protocol based on the differences of source memory among the three kinds of individuals. Either the crime-related probe (e.g., the stolen ring) or one of the crime-unrelated stimuli (e.g., watch, earring, bracelet, or bangle) (item memory) was presented in the first part of each trail, and either a stealing-source word (e.g., stole) or other-source word (e.g., fetched) (source memory) was presented in the second part of each trail. The results showed that: (1) the P300 evoked by item memory could effectively discriminated the guilty from the unknowledgeable innocent (AUC = 0.76) but failed to effectively discriminate the guilty from the knowledgeable innocent (AUC = 0.60); (2) the late positive component evoked by source memory could effectively discriminated the guilty from both the knowledgeable innocent (AUC = 0.94) and the unknowledgeable innocent (AUC = 0.84) in one test.