Conturie Charlotte L, Lyell Deirdre J
The Department of Obstetrics and Gynecology and the Division of Maternal-Fetal Medicine, Stanford University School of Medicine, Stanford, California, USA.
Curr Opin Obstet Gynecol. 2022 Apr 1;34(2):90-99. doi: 10.1097/GCO.0000000000000773.
Placenta accreta spectrum (PAS) is a major cause of severe maternal morbidity. Perinatal outcomes are significantly improved when PAS is diagnosed prenatally. However, a large proportion of cases of PAS remain undiagnosed until delivery.
The prenatal diagnosis of PAS requires a high index of suspicion. The first step is identifying maternal risk factors. The most significant risk factor for PAS is the combination of a prior caesarean delivery and a placenta previa. Other major risk factors include a prior history of PAS, caesarean scar pregnancy (CSP), uterine artery embolization (UAE), intrauterine adhesions (Asherman syndrome) and endometrial ablation.Ultrasound is the preferred imaging modality for the prenatal diagnosis of PAS and can be highly accurate when performed by a provider with expertise. PAS can be diagnosed on ultrasound as early as the first trimester. MRI may be considered as an adjunct to ultrasound imaging but is not routinely recommended. Recent consensus guidelines outline the ultrasound and MRI markers of PAS.
Patients with major risk factors for PAS warrant dedicated ultrasound imaging with a provider experienced in the prenatal diagnosis of PAS.
胎盘植入谱系疾病(PAS)是导致孕产妇严重发病的主要原因。产前诊断PAS可显著改善围产期结局。然而,很大一部分PAS病例直到分娩时才被诊断出来。
PAS的产前诊断需要高度的怀疑指数。第一步是识别母体风险因素。PAS最显著的风险因素是既往剖宫产史和前置胎盘。其他主要风险因素包括既往PAS病史、剖宫产瘢痕妊娠(CSP)、子宫动脉栓塞术(UAE)、宫腔粘连(阿谢曼综合征)和子宫内膜消融术。超声是PAS产前诊断的首选成像方式,由专业人员操作时可具有很高的准确性。PAS最早在孕早期即可通过超声诊断。MRI可作为超声成像的辅助手段,但不常规推荐。最近的共识指南概述了PAS的超声和MRI标志物。
具有PAS主要风险因素的患者需要由有PAS产前诊断经验的专业人员进行专门的超声成像检查。