Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cellular & Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Mini Rev Med Chem. 2022;22(17):2299-2307. doi: 10.2174/1389557522666220301143113.
Today, finding natural polymers with desirable properties for use in various industries is one of the critical axes of research in the world. Polysaccharides are a group of natural polymers that have various applications in the pharmaceutical industry. The attachment of monosaccharides forms polysaccharides through glycosidic bonds that are widely found in various sources, including plants. Genus Astragalus belongs to the Fabaceae family. Plants belonging to this genus have different polysaccharides. Astragalus polysaccharides (APS) have attracted a great deal of attention among natural polymers because they are non-toxic, biodegradable, and biocompatible. Currently, APS have great drug potential for curing or treating various diseases. Due to the different biological activities of polysaccharides, including Astragalus, this study has investigated the chemical structure of APS, reporting on the antiviral and anti-inflammatory activities as well as stimulation of cytokine secretion by these polysaccharides. Also, in this study, the pharmaceutical approaches of APS compounds, as a natural, new and inexpensive source, have been discussed as suitable candidates for use in pharmaceutical formulations and preparation of new drugs to control COVID-19 infection.
如今，寻找具有理想特性的天然聚合物，以应用于各个行业，是世界研究的关键方向之一。多糖是一组天然聚合物，在制药行业中有多种应用。单糖的连接通过糖苷键形成多糖，糖苷键广泛存在于各种来源，包括植物。黄芪属属于豆科。该属的植物含有不同的多糖。黄芪多糖（APS）作为一种无毒、可生物降解和生物相容的天然聚合物，引起了人们的极大关注。目前，APS 在治疗或治疗各种疾病方面具有很大的药物潜力。由于包括黄芪在内的多糖具有不同的生物活性，因此本研究调查了 APS 的化学结构，报告了这些多糖的抗病毒和抗炎活性以及细胞因子分泌的刺激作用。此外，在这项研究中，还讨论了 APS 化合物作为一种天然、新颖且廉价的来源的药物方法，作为用于药物制剂和制备新药物以控制 COVID-19 感染的合适候选物。
