Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Chongqing Medical University, No.74, Linjiang Rd, Yuzhong Dist, Chongqing 404100, P.R. China.
Curr Med Imaging. 2022;18(9):970-976. doi: 10.2174/1573405618666220225090944.
Triple negative breast cancers are considered the worst prognosis in breast cancer. Dynamic contrast enhanced magnetic resonance imaging has been widely used in the diagnosis of breast cancer since it is more sensitive to breast cancer. However, few studies report the MRI characteristics of triple negative breast cancers.
The study aimed to evaluate the imaging finding in triple negative breast cancers compared with non-TNBC and attempt to predict it.
223 patients with a preoperative diagnosis of breast cancer were enrolled in the study. Dynamic contrast enhanced magnetic resonance imaging was performed before being diagnosed with breast cancer, and histopathological assessment was confirmed after biopsy or operation. The patients were divided into 2 groups based on immunohistochemistry, namely the triple negative breast cancers or non-triple negative breast cancers.
The 2 groups demonstrated significant differences regarding the tumor size, margin, outline, burr sign, enhancement, inverted nipple(P<0.05). A multivariate logistic regression analysis was performed to further validate the association of these features, however, only margin [odds ratio (OR), 0.038; 95% confidence interval (CI), 0.014-0.100; <0.001], outline [odds ratio (OR), 0.039; 95% confidence interval (CI), 0.008-0.200; <0.001], burr sign [odds ratio (OR), 2.786; 95% confidence interval (CI), 1.225-6.333; 0.014], and enhancement [odds ratio (OR), 0.131; 95% confidence interval (CI), 0.037-0.457; P=0.001] were associated with TNBC.
The results indicated that the specific dynamic contrast enhanced magnetic resonance imaging features can predict pathological results, with a consequent prognostic value.
三阴性乳腺癌被认为是乳腺癌中预后最差的一种。动态对比增强磁共振成像因其对乳腺癌更敏感，已广泛应用于乳腺癌的诊断。然而，很少有研究报道三阴性乳腺癌的 MRI 特征。
本研究旨在评估三阴性乳腺癌与非三阴性乳腺癌的影像学表现，并尝试对其进行预测。
本研究纳入了 223 例术前诊断为乳腺癌的患者。所有患者均在术前进行了动态对比增强磁共振成像检查，在活检或手术后通过组织病理学评估来确认诊断。根据免疫组织化学结果，将患者分为三阴性乳腺癌组和非三阴性乳腺癌组。
两组在肿瘤大小、边缘、轮廓、毛刺征、强化方式、乳头内陷等方面存在显著差异（P<0.05）。多因素逻辑回归分析进一步验证了这些特征的相关性，但只有边缘[比值比（OR），0.038；95%置信区间（CI），0.014-0.100；<0.001]、轮廓[OR，0.039；95%CI，0.008-0.200；<0.001]、毛刺征[OR，2.786；95%CI，1.225-6.333；0.014]和强化方式[OR，0.131；95%CI，0.037-0.457；P=0.001]与三阴性乳腺癌相关。
这些结果表明，特定的动态对比增强磁共振成像特征可以预测病理结果，具有一定的预后价值。
