Protsenko Maria, Kerkelä Martta, Miettunen Jouko, Auvinen Juha, Järvelin Marjo-Riitta, Jones Peter B, Gissler Mika, Veijola Juha
Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland.
Center for Life Course Health Research, University of Oulu, Oulu, Finland.
Psychol Med. 2023 Jun;53(8):3621-3627. doi: 10.1017/S0033291722000253. Epub 2022 Mar 2.
People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass index (BMI) in middle-aged offspring. Our objective was to determine if the offspring of either parent with SMI have an increased risk for obesity.
The Northern Finland Birth Cohort 1966 is a cohort study of offspring with expected date of birth in 1966. The data include originally 12 068 mothers and 12 231 children from the provinces of Lapland and Oulu in Finland. The final study sample included 5050 middle-aged offspring. Parental SMI was used as exposure in the study. BMI measured at the age of 46 years was used as a primary outcome.
Risk for obesity was elevated in the offspring of mothers with SMI [overweight: adjusted odds ratio (OR) 1.93 (1.29-2.90), obese class I: 1.97 (1.20-3.25), obese classes II-III: 2.98 (1.67-5.33)]. For the offspring of either parent with SMI, statistically significant results were found in obese class I and obese classes II-III [overweight: adjusted OR 1.21 (0.94-1.54), obese class I: 1.52 (1.03-1.08), obese classes II-III: 1.53 (1.01-2.32)].
We found an elevated risk of obesity in the middle-aged offspring of either parent with SMI, especially in the offspring of mothers with SMI. Thus, there might be a common familial pathway leading to the co-occurrence of obesity and SMI.
严重精神疾病（SMI）患者肥胖风险升高，但其原因和机制尚不清楚。我们探讨了中年子代中父母患严重精神疾病与体重指数（BMI）之间的家族关联。我们的目的是确定父母一方患有严重精神疾病的子代是否肥胖风险增加。
1966年芬兰北部出生队列是一项对预期出生日期为1966年的子代进行的队列研究。数据最初包括来自芬兰拉普兰省和奥卢省的12068名母亲和12231名儿童。最终研究样本包括5050名中年子代。研究中以父母患严重精神疾病作为暴露因素。将46岁时测量的BMI作为主要结局指标。
母亲患有严重精神疾病的子代肥胖风险升高[超重：校正比值比（OR）1.93（1.29 - 2.90），I级肥胖：1.97（1.20 - 3.25），II - III级肥胖：2.98（1.67 - 5.33）]。父母一方患有严重精神疾病的子代，在I级肥胖和II - III级肥胖中发现有统计学意义的结果[超重：校正OR 1.21（0.94 - 1.54），I级肥胖：1.52（1.03 - 1.08），II - III级肥胖：1.53（1.01 - 2.32）]。
我们发现父母一方患有严重精神疾病的中年子代肥胖风险升高，尤其是母亲患有严重精神疾病的子代。因此，可能存在一条共同的家族途径导致肥胖和严重精神疾病的共同发生。
