Power Chris, Pouliou Theodora, Li Leah, Cooper Rachel, Hyppönen Elina
MRC Centre of Epidemiology for Child Health, Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK.
Ann Hum Biol. 2011 Jul;38(4):390-9. doi: 10.3109/03014460.2011.591827. Epub 2011 Jun 15.
BACKGROUND/AIMS: Parent-offspring adiposity associations are well-established: offspring of obese parents have elevated risks of overweight/obesity. The aim of studies based on the 1958 British birth cohort has been to gain insights into explanations of these associations, such as whether parent-offspring BMI associations are due to offspring lifestyles or depend on socio-economic conditions.
All major studies on intergenerational adiposity associations in the three generations of the 1958 birth cohort were reviewed. In addition, BMI data for parents (G1) and the cohort (G2) were analysed stratified by social class.
BMI of G1 and G2 were correlated both when offspring were children and in mid-adulthood: a 1 kg/m(2) higher parental BMI was associated with an average 0.24-0.35 kg/m(2) higher offspring (mothers/fathers vs sons/daughters) BMI at 45 years. Associations were little affected by adjustment for lifestyle and socio-economic factors, but varied by social class: average BMI gain in offspring relative to parents was greater in lower classes, e.g. for males vs fathers by 3.6 and 2.5 kg/m(2) in classes IV&V and I&II, respectively. Parent-offspring BMI associations were stronger for recent (G2 and G3) than older (G1 and G2) generations.
Parent-offspring associations in BMI were not explained by offspring lifestyles, but varied over successive generations and by social class, suggesting that intergenerational transmission of adiposity at a population level is modifiable rather than immutable.
背景/目的：父母与子女的肥胖关联已得到充分证实：肥胖父母的子女超重/肥胖风险更高。基于1958年英国出生队列开展研究的目的是深入了解这些关联的原因，比如父母与子女的体重指数（BMI）关联是由于子女的生活方式，还是取决于社会经济状况。
对1958年出生队列三代人中关于代际肥胖关联的所有主要研究进行了综述。此外，还按社会阶层对父母（第一代）和队列人群（第二代）的BMI数据进行了分析。
第二代人的BMI与第一代人在子女儿童期及中年期时均存在相关性：父母BMI每高出1kg/m²，其子女在45岁时的BMI平均高出0.24 - 0.35kg/m²（母亲/父亲与儿子/女儿相比）。生活方式和社会经济因素的调整对这种关联影响不大，但因社会阶层而异：相对于父母，子女BMI的平均增加值在较低阶层更大，例如，在第四和第五阶层以及第一和第二阶层中，男性相对于父亲的BMI增加值分别为3.6kg/m²和2.5kg/m²。父母与子女的BMI关联在较近的几代人（第二代和第三代）中比在较早的几代人（第一代和第二代）中更强。
子女的生活方式并不能解释父母与子女之间的BMI关联，但这种关联在连续几代人之间以及不同社会阶层之间存在差异，这表明在人群层面肥胖的代际传递是可以改变的，而非一成不变的。
