白细胞介素-34 与冠心病合并糖尿病。
IL-34 and coronary heart disease complicated with diabetes mellitus.
机构信息
Department of Cardiac Electrophysiology, Hospital Affiliated to Chengde Medical University, Chengde Hebei 067000.
Department of Endocrinology, Hospital Affiliated to Chengde Medical University, Chengde Hebei 067000, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Dec 28;46(12):1409-1414. doi: 10.11817/j.issn.1672-7347.2021.200797.
Coronary heart disease and diabetes mellitus are closely related to chronic low-grade inflammation. Interleukin-34 (IL-34) is a new member of the interleukin family discovered in recent years. It is involved in the pathophysiological process of mononuclear phagocyte system mainly via binding to colony stimulating factor-1 receptor, and it is closely related to inflammatory and autoimmune diseases. IL-34 is highly expressed in patients with coronary heart disease or diabetes mellitus. IL-34 induces atherosclerosis and insulin resistance through multiple pro-inflammatory actions, ultimately leading to the occurrence and development of coronary heart disease, type 2 diabetes, and their comorbidities.
冠心病和糖尿病与慢性低度炎症密切相关。白细胞介素 34（IL-34）是近年来发现的白细胞介素家族的新成员。它主要通过与集落刺激因子 1 受体结合参与单核吞噬细胞系统的病理生理过程，与炎症和自身免疫性疾病密切相关。IL-34 在冠心病或糖尿病患者中高表达。IL-34 通过多种促炎作用诱导动脉粥样硬化和胰岛素抵抗，最终导致冠心病、2 型糖尿病及其合并症的发生和发展。
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